Characterization and role of extracellular vesicles from Avian Influenza-virus-infected cells in the immune response modulation

• Grant number: 23/14798-6
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2024
• End date: January 31, 2026
• Field of knowledge: Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: Fausto Bruno dos Reis Almeida
• Grantee: Fausto Bruno dos Reis Almeida
• Principal researcher abroad: Miriã Ferreira Criado
• Institution abroad: Auburn University, United States
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 21/06794-5 - Fungal extracellular vesicles: immunomodulation and cellular communication, AP.JP2

Abstract

Avian Influenza Viruses (AIVs) is one of the widely spread viruses in poultry, which threats the global economy and healthy security. Extracellular vesicles (EVs) play important role in the biology of all domains of life. During viral infections, the mechanisms by which EVs from infected cells modulates the host immune system are still poorly explored. Our groups have concentrated efforts to understand the pathological basis for AIV virulence, and how EVs acts as potential immunomodulators. In this proposal, we aim to determine the role of EVs derived from AIV-infected cells in the immune response modulation. More specifically, we propose to do the following aims: (1) To characterize the production of EVs from AIV-infected cells; (2) To assess the ability of EV production from AIV-infected cells to modulate the host immunity; (3) To analyze the influence of EV derived from AIV-infected cells to regulate the host immunity. To understand how EVs derived from IAV infected cells modulate the immune system can be crucial to identify new therapeutic targets and to develop new strategies to combat influenza virus and other viral infections. (AU)