Center of Technological Plataform on Animal Health

• Grant number: 21/11968-2
• Support Opportunities: Research Grants - Science Centers for Development
• Start date: February 01, 2024
• End date: January 31, 2029
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Preventive Veterinary Medicine
• Principal Investigator: Alessandra Figueiredo de Castro Nassar
• Grantee: Alessandra Figueiredo de Castro Nassar
• Host Institution: Instituto Biológico (IB). Agência Paulista de Tecnologia dos Agronegócios (APTA). Secretaria de Agricultura e Abastecimento (São Paulo - Estado). São Paulo , SP, Brazil
• Pesquisadores principais: Clarice Weis Arns ; Helena Lage Ferreira ; João Pessoa Araújo Junior ; Liria Hiromi Okuda
• Associated researchers: Adriana Hellmeister de Campos Nogueira ; Ana Maria Iba Kanashiro ; Bruna Trevisan Souza Szucko ; Cristina Corsi Dib ; Dilmara Reischak ; Edviges Maristela Pituco ; Greice Filomena Zanatta ; Guilherme Shin Iwamoto Haga ; Manuel Jose Sanchez Vazquez ; Marcelo Camargo Fernandes ; Patricia Helena Nogueira Turco ; Renata Martins Sampaio ; Renato Luís Luciano
• Associated scholarship(s): 25/09023-0 - Point-of-care platform for diagnosis via LAMP-CRISPR-Cas12a of Avian Reovirus (ARV) and Infectious Bursal Disease Virus (IBDV)., BP.DR; 25/10812-0 - Development and Standardization of the SHERLOCK (Specific High-Sensitivity Enzymatic Reporter Unlocking) Platform Combined with Lateral Flow Assay for Rapid Diagnosis of Infectious Laryngotracheitis and Avian Infectious Bronchitis, BP.PD; 25/06071-4 - Development and validation of a biomarker panel for rapid detection of Bluetongue virus in samples from ruminants and insect vectors of the genus Culicoides, BP.PD; 25/00866-5 - DEVELOPMENT OF A RAPID TEST FOR THE IDENTIFICATION OF AVIAN INFLUENZA VIRUSES, BP.DR; 25/06269-9 - Point-of-Care Diagnostic Device for Avian Infections: Development of a LAMP/RPA System Coupled with NALFIA, BP.PD

Abstract

The covid-19 pandemic brought a new perspective on health, showing that in a short period of time and with multidisciplinary approaches, it is possible to develop more effective technologies to enable more effective procedures and/or inputs to be used in the laboratory diagnosis of infectious diseases. This same type of strategy can be adopted to solve other major emerging or even endemic health problems that affect farm animals. In this sense, it is clear and urgent the need to create the Center for Technological Platform in Animal Health, headquartered at the Biological Institute, in partnership with the Animal Health Defense Service, São Paulo state universities, in addition to international institutions of reference to the Organization World Animal Health (OIE), for a Single Health, aiming to contribute to a more effective control of sanitary problems affecting the productive sector. This proposal aims to define the main biomarkers to be applied in the development and standardization of rapid tests for diagnosing highly relevant infectious diseases in two chains of the livestock sector (cattle and poultry). Through in silico and laboratory approaches, the characterization of biomarkers will be directed towards viral diseases in cattle (blue tongue) and birds (avian influenza, Newcastle disease, infectious avian laryngotracheitis, infectious bronchitis in chickens and avian metapneumovirus). The standardization and validation of the tests will use samples from the Biological Materials Collection of the Biological Institute and reference materials from national and international institutions. The cost-benefit analysis of the proposed tests will also be determined, as well as the assessment of the feasibility of applying the methods with the Official Service of the State of São Paulo. The proposed Center will have the Partnership Committee to prospect and enable the inclusion of companies and startups in the private sector, bringing the contribution of investments that will ensure the production and standardization of the tests developed on a larger scale. The Communication Committee will contribute to the dissemination of the results achieved by the Platform and the training of human resources to act in the control and prevention of the sanitary problems. In this way, it is intended that this Center can respond to the relevant sanitary demands of the productive sector of the national livestock sector, contributing to the surveillance and control of infectious diseases for cattle and poultry in our country. (AU)