Interactions of hydrogen sulfide (H2S) with the novel endogenous catecholamines 6-nitrodopamine and 6-cyanodopamine in rabbit isolated vascular tissues.

• Grant number: 25/01272-1
• Support Opportunities: Research Grants - Visiting Researcher Grant - International
• Start date: August 01, 2025
• End date: August 31, 2025
• Field of knowledge: Biological Sciences - Pharmacology - Cardiorenal Pharmacology
• Principal Investigator: Gilberto de Nucci
• Grantee: Gilberto de Nucci
• Visiting researcher: Andreas Papapetropoulos
• Visiting researcher institution: National And Kapodistrian University Of Athens/Nkua, Greece
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 19/16805-4 - Evaluation of the pathophysiological role of endothelial catecholamines, AP.TEM

Abstract

Andreas Papapetropoulos is a full professor of Pharmacology at the Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Athens. Professor Papapetropoulos is a word expert on the pharmacology of H2S. Hydrogen sulfide has emerged as an endogenous regulator of a broad range of physiological functions; it belongs to the class of molecules known as gasotransmitters, which typically include nitric oxide (NO) and carbon monoxide (CO). Our group has recently identified novel endothelium-derived catecholamines, such as 6-nitrodopamine and 6-cyanodopamine, which are potent vasodilators. The visit by Prof Papapetropoulous will allow us to investigate whether H2S presents pharmacological interactions with these novel endogenous catecholamines. (AU)