New Synthetic Routes to Rolipram and Baclofen

• Grant number: 24/22222-0
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2025
• End date: May 31, 2027
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Liliana Marzorati
• Grantee: Liliana Marzorati
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Baclofen and Rolipram are 3-Substituted GABA derivatives, used to treat various neurological disorders. Baclofen is quite efficient to treat spasticity, and Rolipram has been proposed to lessen the symptoms of multiple sclerosis and to have antipsychotic effects. In view of the importance of Baclofen and Rolipram, new routes for their synthesis are important challenges to the organic chemist. The present research project proposes some new routes, starting from less expensive reagents, and envisages simple synthetic processes. (AU)