EFFICACY AND SAFETY OF A WHOLE-BODY VIBRATION PROTOCOL COMBINED WITH PULMONARY REHABILITATION IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A PROSPECTIVE RANDOMIZED SINGLE-BLIND CONTROLLED CLINICAL STUDY

• Grant number: 24/14756-4
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2025
• End date: August 31, 2028
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Marise Lazaretti Castro
• Grantee: Marise Lazaretti Castro
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated researchers: Fernando Cezar Alves de Salles ; Franciele De Meneck ; ilda sizue kunii ; José Roberto de Brito Jardim ; Mônica Longo de Oliveira ; Oliver Augusto Nascimento ; Rafael Francisco Vieira de Melo ; Rodrigo Nolasco dos Santos

Abstract

Introduction: Chronic Obstructive Pulmonary Disease (COPD) is associated with sarcopenia and osteoporosis, limiting quality of life. Whole-body mechanical vibration (WBV) may be a promising intervention. Objective: To assess the impact of WBV on bone quality, neuromuscular function, and respiratory capacity in patients with COPD. Methods: In a prospective, single-blind intervention study, 80 patients with mild to moderate stages of COPD will be selected and included in a randomized prospective study. Patients will be randomly assigned to two groups: the Control Group will remain on a turned-off vibrating platform for 20 minutes, while the Intervention Group will remain on a vibrating platform for 20 minutes. Activities will take place 3 times per week over a 12-week period. After these 12 weeks, the placebo group will be given the opportunity to participate in the vibration program for an additional 12 weeks. Fasting blood samples will be collected at baseline, after 6 and 12 weeks for biochemical and hormonal marker assays. At the beginning and end of the 12 weeks, the following parameters will be evaluated: functional capacity (including endurance, balance, and strength), respiratory function (via spirometry), bone structure and metabolism, including bone mineral density, high-performance peripheral quantitative computed tomography, body composition by DXA, and assessment of peripheral perfusion through thermography. Expected Results: The results are expected to provide information on the effects of WBV on bone quality and neuromuscular and cardiorespiratory functions in COPD patients, contributing to more effective rehabilitation approaches. (AU)