Effects of maternal deprivation on two different ages of neonatal development on depressive-related behaviours in adolescent male rats

• Grant number: 25/18220-4
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2026
• End date: November 30, 2027
• Field of knowledge: Biological Sciences - Pharmacology - Neuropsychopharmacology
• Principal Investigator: Deborah Suchecki
• Grantee: Deborah Suchecki
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• City of the host institution: São Paulo
• Associated research grant: 23/13464-7 - Resilience and vulnerability to stress-related psychiatric disorders induced by stress during neurodevelopment: the role of neuroinflammation, AP.TEM

Abstract

Depressive disorder is characterized by anhedonia, self-care impairment, persistent sadness and negative thoughts for, at least, two weeks. Exposure to stress during infancy and adolescence, periods when the brain undergoes intense changes and maturation, may increase the risk to paychiatric disorders in adulthood. The purpose of the present proposal is to assess the effects of maternal deprivation (DEP) in two ages of the neonatal development, associated or not to a traumatic stimuli during adolescence in male rats, on depression-like behaviours. To this end, whole litters will be assigned to control (CTL), maternal deprivation on day 3 (DEP3) or on day 11 (DEP11) groups. At weaning, the (AU)