Molecular biology and immunobiology of purified exocellular components of Paracoccidioides brasiliensis: relation between structure and function

• Grant number: 95/00559-8
• Support Opportunities: Research Projects - Thematic Grants
• Start date: September 01, 1995
• End date: November 30, 1998
• Field of knowledge: Biological Sciences - Immunology
• Principal Investigator: Luiz Rodolpho Raja Gabaglia Travassos
• Grantee: Luiz Rodolpho Raja Gabaglia Travassos
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

The integrated project comprises 3 lines of investigation involving purified molecules of Paracoccidioides brasiliensis aiming principally to correlate structure and function, and its importance in the pathology of paracoccidioidomicosis (PCM). The 3 lines involve principally the expression of the principal diagnostic antigen of PCM in appropriate vectors, the biochemical and molecular biological study of a serine(tiol) protease recently described in our laboratory, as well as the identification of the epitopes of gp43 responsible for protective immunocellular reactions in PCM. (AU)