| Grant number: | 05/59360-0 |
| Support Opportunities: | Research Projects - Thematic Grants |
| Start date: | November 01, 2006 |
| End date: | August 31, 2011 |
| Field of knowledge: | Physical Sciences and Mathematics - Chemistry - Analytical Chemistry |
| Principal Investigator: | Fernando Mauro Lanças |
| Grantee: | Fernando Mauro Lanças |
| Host Institution: | Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil |
| City of the host institution: | São Carlos |
Abstract
The commercial development of instrumental chromatography, which occurred from the decade of the 50s onwards, has enabled the analysis (qualitative and quantitative) of increasingly smaller analytes present in increasingly complex matrixes. However, the efforts begun particularly in the decade of the 80s, aimed at a miniaturization of these systems, and their innumerable advances, have still both reached the great user public. The large companies producing the equipment still continue to offer instruments very similar to those existing in the decade of the 80s, with small, usually inadequate adaptations. The experience of the proposing group in the last 15 years in the development of chromatographs and accessories (columns, detectors, data systems), extractors for supercritical fluids and accelerated extraction with solvents, micro-extraction in solid phase, and others, suggests that the best alternative for miniaturization of equipment for separation techniques, for the next 30 years, would be of intermediary dimensions and technology between the "macro systems, popular at present, and the systems based on "microchips, a probable alternative for a more distant future. With a real base in the experience involved with the development of various items of equipment and accessories for this area, what is proposed in this project is the conclusion of the miniaturization of a gas chromatograph under development; the development of a piece of equipment for micro-LC; the development of new components, interfaces and accessories for micro-LC, SPME and SBSE; and the development of new systems of acquisition and treatment of data for chromatography, as well as the application of the same in the analysis of various complex samples such as those of environmental interest (pollutants), public health (medicines in biological fluids, chemotherapies, and drugs of abuse), foodstuffs (pesticides and drinks) and fuels (with adulterants). (AU)
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