Parameters for the evaluation of the severity of experimental paracoccidioidomycosis in strains of susceptible and resistant mice and their F1 progeny

• Grant number: 96/05335-3
• Support Opportunities: Research Projects - Thematic Grants
• Start date: May 01, 1997
• End date: May 31, 2000
• Field of knowledge: Biological Sciences - Immunology
• Principal Investigator: Eva Burger
• Grantee: Eva Burger
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant(s): 98/15917-5 - Influence of the genetic background in the pattern of lesions developed by resistant and susceptible mice..., PUB.ART

Abstract

The project aims to establish some parameters for monitoring the development of paracoccidioidomycosis of greater or lesser severity in susceptible, resistant and first generation hybrid mice, infected with fungic isolates varying in virulence. In the course of the infection we will research the production of inhibitory cytokine TGF B, the occurrence of antigenemia, the architecture and cell and matricial composition of granulomatous lesions, as well as the existence of seric and hematological biochemical alterations, both at the level of peripheral blood as well as medullary and splenetic haemopoiesis. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CLEMONS‚ KV; CALICH‚ VLG; BURGER‚ E.; FILLER‚ SG; GRAZIUTTIT‚ M.; MURPHY‚ J.; ROILIDES‚ E.; CAMPA‚ A.; DIAS‚ MR; JR‚ J.E.E.; et al. Pathogenesis I: interactions of host cells and fungi. Medical Mycology, v. 38, n. s1, p. 99-111, 2000. (96/05335-3)