Characterization and simulation of biological networks

• Grant number: 07/02827-9
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2007
• End date: July 31, 2009
• Field of knowledge: Physical Sciences and Mathematics - Physics - Condensed Matter Physics
• Principal Investigator: Ney Lemke
• Grantee: Ney Lemke
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

The development of high throughput biomolecular techniques encompassing different aspects of cellular behavior is generating huge amounts of data. The challenge now is to develop new analysis techniques to extract relevant biological information from these data. In this project we will build, characterize and simulate integrated biological networks involving metabolism, protein-protein interaction and gene regulation. We will use different artificial intelligence and simulation techniques, such as: decision trees, molecular dynamics and bayesian networks, aiming to determine gene functions and essentiality and new targets for drugs. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CECHIN, ADELMO L.; SINIGAGLIA, MARIALVA; MOMBACH, JOSE C. M.; ECHEVERRIGARAY, SERGIO; LEMKE, NEY; CABRERA, ODALYS G.; PEREIRA, GONCALO A. G.; MEDRANO, FRANCISCO JAVIER. Can Nep1-like proteins form oligomers?. PLANT SIGNALING & BEHAVIOR, v. 3, n. 10, p. 906-907, 2008. (07/02827-9)

ACENCIO, MARCIO L.; LEMKE, NEY. Towards the prediction of essential genes by integration of network topology, cellular localization and biological process information. BMC Bioinformatics, v. 10, SEP 16 2009. (07/02827-9, 07/01213-7)

COSTA‚ P.R.; ACENCIO‚ M.L.; LEMKE‚ N.. A machine learning approach for genome-wide prediction of morbid and druggable human genes based on systems-level data. BMC Genomics, v. 11, n. Suppl 5, p. S9, 2010. (07/02827-9, 07/01213-7, 07/08466-8)

CECHIN‚ A.; SINIGAGLIA‚ M.; LEMKE‚ N.; ECHEVERRIGARAY‚ S.; CABRERA‚ O.; PEREIRA‚ G.; MOMBACH‚ J.. Cupin: A candidate molecular structure for the Nep1-like protein family. BMC PLANT BIOLOGY, v. 8, n. 1, p. 50, 2008. (07/02827-9)