Development of molecular markers related to cellular resistance after photodynamic therapy in breast carcinomas

• Grant number: 09/18440-1
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2010
• End date: January 31, 2013
• Field of knowledge: Engineering - Biomedical Engineering
• Principal Investigator: Renata de Azevedo Canevari
• Grantee: Renata de Azevedo Canevari
• Host Institution: Instituto de Pesquisa e Desenvolvimento (IP&D). Universidade do Vale do Paraíba (UNIVAP). São José dos Campos , SP, Brazil
• City of the host institution: São José dos Campos

Abstract

Breast cancer is an extremely complex disease and clinically heterogeneous, characterized by very different prognoses among patients. The heterogeneity of these tumors is also evidenced by the large number of genes that are related to control of growth, death and differentiation. The main problem of such disorder is the recurrence rate after therapy, where more than half of affected patients suffer recurrence. Several clinical, pathological and molecular techniques have been proposed for predicting the recurrence of this tumor. However, to date, the ability to predict the risk of recurrence in patients with breast cancer is not fully effective in an individual. Recently, photodynamic therapy is an alternative that is being used successfully in the treatment of many solid tumors, may be an alternative for tumor reduction. However, despite the important innovations, the mechanism of cellular resistance and subsequent recurrence is also frequently observed in most tumors undergoing this therapy. Thus, to understand the tumor biology, complementing the classical clinicopathological analysis and thereby ensure a better characterization and treatment of breast tumors, further studies on the effect of the application of PDT are needed Considering these aspects, this project have as objective detected markers or molecular pathways that may be related to cellular resistance and subsequent recurrence of tissues undergoing photodynamic therapy, besides to studying the cellular mechanism of this therapy through the combination of analysis gene expression, protein expression and morphological analysis, thus enabling a better understanding of the effect of the application of PDT and thereby provide a better characterization and treatment of breast tumors. (AU)

Scientific publications

(9)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

DA SILVA, RAISSA MONTEIRO; PUPIN, BRENO; BHATTACHARJEE, TANMOY TAPOBRATA; VAMONDES KULCSAR, MARCO AURELIO; UNO, MIYUKI; CHAMMAS, ROGER; CANEVARI, RENATA DE AZEVEDO. ATR-FTIR spectroscopy and CDKN1C gene expression in the prediction of lymph nodes metastases in papillary thyroid carcinoma. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, v. 228, MAR 5 2020. (13/14464-9, 09/18440-1)

RICCI, R.; LEITE, N. C. S.; DA-SILVA, N. S.; PACHECO-SOARES, C.; CANEVARI, R. A.; MARCIANO, F. R.; WEBSTER, T. J.; LOBO, A. O.. Graphene oxide nanoribbons as nanomaterial for bone regeneration: Effects on cytotoxicity, gene expression and bactericidal effect. Materials Science & Engineering C-Materials for Biological Applications, v. 78, p. 341-348, SEP 1 2017. (11/17877-7, 11/20345-7, 13/14464-9, 13/20054-8, 15/09697-0, 09/18440-1, 16/00575-1)

SILVA, J. C.; FERREIRA-STRIXINO, J.; FONTANA, L. C.; PAULA, L. M.; RANIERO, L.; MARTIN, A. A.; CANEVARI, R. A.. Apoptosis-associated genes related to photodynamic therapy in breast carcinomas. Lasers in Medical Science, v. 29, n. 4, p. 1429-1436, JUL 2014. (10/00488-5, 11/09523-0, 09/18440-1)

NETO, LAZARO P. M.; DOS SANTOS, LAURITA; CARVALHO, LUIS FELIPE C. S.; SANTOS, ANDRE B. O.; MARTIN, AIRTON A.; CANEVARI, RENATA A.. Integrating Raman spectroscopy and RT-qPCR for enhanced diagnosis of thyroid lesions: A comparative study of biochemical and molecular markers. Journal of Pharmaceutical and Biomedical Analysis, v. 261, p. 10-pg., 2025-08-15. (09/18440-1, 13/14464-9, 14/05978-1)

RYMSZA, TACIANA; RIBEIRO, ELIANE ALINE; DAS CHAGAS E SILVA DE CARVALHO, LUIS FELIPE; BHATTACHARJEE, TANMOY; CANEVARI, RENATA DE AZEVEDO. Human papillomavirus detection using PCR and ATR-FTIR for cervical cancer screening. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, v. 196, p. 238-246, MAY 5 2018. (13/14464-9, 09/18440-1, 14/05978-1)

SILVA SOARES, LUIS EDUARDO; MAGALHAES, JUAREZ DA SILVA; MARCIANO, FERNANDA ROBERTA; LOBO, ANDERSON OLIVEIRA. Surface characteristics of a modified acidulated phosphate fluoride gel with nano-hydroxyapatite coating applied on bovine enamel subjected to an erosive environment. MICROSCOPY RESEARCH AND TECHNIQUE, v. 81, n. 12, p. 1456-1466, DEC 2018. (11/17877-7, 11/20345-7, 13/14464-9, 07/07984-5, 09/18440-1)

DA SILVA, RAISSA MONTEIRO; SANTOS, JOYCE NASCIMENTO; UNO, MIYUKI; CHAMMAS, ROGER; VAMONDES KULCSAR, MARCO AURELIO; SANT'ANNA, LUCIANA BARROS; CANEVARI, RENATA DE AZEVEDO. CCNA1 gene as a potential diagnostic marker in papillary thyroid cancer. ACTA HISTOCHEMICA, v. 122, n. 8, DEC 2020. (09/18440-1, 13/14464-9)

QUEIROZ, JOAO PAULO DA SILVA; PUPIN, BRENO; BHATTACHARJEE, TANMOY TAPOBRATA; UNO, MIYUKI; CHAMMAS, ROGER; KULCSAR, MARCO AURELIO VAMONDES; CANEVARI, RENATA DE AZEVEDO. Expression data of FOS and JUN genes and FTIR spectra provide diagnosis of thyroid carcinoma. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, v. 304, p. 8-pg., 2024-01-05. (19/10211-5, 09/18440-1, 13/14464-9)

PUPIN, BRENO; DINIZ, RAMON VARELLA; COSTA, MARICILIA SILVA; CHAGAS, MAURILIO JOSE; SANTOS, ANDRE BANDIERA DE OLIVEIRA; CANEVARI, RENATA DE AZEVEDO. Molecular Markers for Thyroid Cancer Diagnosis: Insights from MAPK Pathway Gene Expression Analysis. BIOMEDICINES, v. 13, n. 7, p. 15-pg., 2025-06-27. (09/18440-1, 13/14464-9)