Study of the organization and of the neuronal dynamics: neuroanal death and neurogenesis of the rats brain after neonatal anoxia

• Grant number: 10/01488-9
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2010
• End date: May 31, 2012
• Field of knowledge: Biological Sciences - Morphology - Anatomy
• Principal Investigator: Maria Inês Nogueira
• Grantee: Maria Inês Nogueira
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Luiz Fernando Takase ; Mario Hiroyuki Hirata

Abstract

Previous studies of our laboratory developed an animal model, rats, for the study of the neonatal anoxia. Hereby we plan to explore the neuronal dynamics: neurogenesis, maturation and cell death (necrosis and apoptosis) in the rats brain by longitudinally analyzing the brain with immunehistochemical reactions using specific anti-bodies for the mentioned process at the periods of days P2, P7, P14, P21 e P60 after neonatal anoxia stimulus. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TAKADA, S. H.; DOS SANTOS HAEMMERLE, C. A.; MOTTA-TEIXEIRA, L. C.; MACHADO-NILS, A. V.; LEE, V. Y.; TAKASE, L. F.; CRUZ-RIZZOLO, R. J.; KIHARA, A. H.; XAVIER, G. F.; WATANABE, I. -S.; et al. NEONATAL ANOXIA IN RATS: HIPPOCAMPAL CELLULAR AND SUBCELLULAR CHANGES RELATED TO CELL DEATH AND SPATIAL MEMORY. Neuroscience, v. 284, p. 247-259, JAN 22 2015. (11/19747-3, 10/01488-9)

TAKADA, SILVIA HONDA; MOTTA-TEIXEIRA, LIVIA CLEMENTE; MACHADO-NILS, ALINE VILAR; LEE, VITOR YONAMINE; SAMPAIO, CARLOS ALBERTO; POLLI, ROBERSON SARAIVA; MALHEIROS, JACKELINE MORAES; TAKASE, LUIZ FERNANDO; KIHARA, ALEXANDRE HIROAKI; COVOLAN, LUCIENE; et al. Impact of neonatal anoxia on adult rat hippocampal volume, neurogenesis and behavior. Behavioural Brain Research, v. 296, p. 331-338, JAN 1 2016. (10/01488-9)