Inflammatory response and C5 dependent genetic expression in mouse liver injury

• Grant number: 09/05979-0
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2009
• End date: August 31, 2011
• Field of knowledge: Biological Sciences - Immunology - Immunogenetics
• Principal Investigator: Lourdes Isaac
• Grantee: Lourdes Isaac
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Sub-Project 1. We will study the role of C5 in the inflammatory response and gene expression in the liver after injury induced by ethanol treatment. The inflamamtory response will be evaluated in vivo by histopathological analyses, productions of cytokines (IL-6, IL-10, IL-12 e TNF-alfa)in the liver in the presence and absence of complement C5. Sub-project 2. We will study the structural requirement of Factor H for its secretion. Sub-project 3. We will study the correlation of low levels of complement activity and development of prostate cancer. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SILVA, ALDACILENE SOUZA; CASTIBLANCO VALENCIA, MONICA MARCELA; CIANCIARULLO, AURORA MARQUES; VASCONCELLOS, SILVIO ARRUDA; BARBOSA, ANGELA SILVA; ISAAC, LOURDES. Interaction of human complement factor H variants Tyr(402) and His(402) with Leptospira spp.. FRONTIERS IN IMMUNOLOGY, v. 2, 2011. (10/50043-0, 09/05979-0)