Effects of corticosterone on the regulation of cell proliferation and expression of TGF alpha and EGFR in the gastric mucosa of rats under postnatal development

• Grant number: 09/00272-5
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2009
• End date: May 31, 2011
• Field of knowledge: Biological Sciences - Morphology - Cytology and Cell Biology
• Principal Investigator: Patrícia Gama
• Grantee: Patrícia Gama
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Maternal milk is a rich source of nutrients and active regulatory peptides. Early weaning induces changes in the growth and development of the stomach, such as the precocious maturation of cell populations. We have previously shown that during early weaning TGF alpha and EGFR production increases, and both might be involved in the stimulus of proliferation and differentiation. Glucocorticoids could also be part of the mechanism of regulation of growth. However, there are no studies comparing high glucocorticoids levels during early weaning to the induced expression of TGF alpha and EGFR. In the current study we aim to study the levels of total and free corticosterone during early weaning, and from that study the proliferative response and production of TGF alpha and EGFR in the gastric mucosa after the inhibiting glucocorticoid receptor with RU 38486 antagonist. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VALENTE RAMOS BITTAR, NATALIA MARTINS; ZULIAN, JULIANA GUIMARAES; OGIAS, DANIELA; GAMA, PATRICIA. Ghrelin and GHS-R in the rat gastric mucosa: Are they involved in regulation of growth during early weaning?. NUTRITION, v. 32, n. 1, p. 101-107, JAN 2016. (09/00272-5, 11/17415-3)

GHIZONI, HELOISA; FIGUEIREDO, PRISCILA MOREIRA; MOISAN, MARIE-PIERRE; OGIAS, DANIELA; OSAKI, LUCIANA HARUMI; GAMA, PATRICIA. Regulation of corticosterone function during early weaning and effects on gastric cell proliferation. NUTRITION, v. 30, n. 3, p. 343-349, MAR 2014. (09/00272-5, 11/17415-3, 10/03059-8)