Efficacy of terlipressin versus epinephrine in cardiopulmonary resuscitation in pigs

• Grant number: 07/08315-0
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2008
• End date: February 28, 2010
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Sebastião Araujo
• Grantee: Sebastião Araujo
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The main objective of this study is to evaluate the effectiveness of terlipressin (TP) versus adrenaline (ADR) for increasing coronary perfusion pressure (CPP) and the return of the spontaneous circulation (ROSC) in the cardiopulmonary resuscitation (CPR) of pigs submitted to cardiac arrest (CA) in ventricular fibrillation (VF). We expect to demonstrate that TP can be more efficient than the adrenaline (ADR) as a vasopressor during CPR. Twenty four animals will be randomly assigned into three equal groups: 1) ADR, 2) TP and 3) TP + ADR. After the induction of VF, the animals will remain in non-assisted CA for 10 minutes. After this time, the American Heart Association (AHA) basic life support CPR (BLS-CPR) protocol will be applied for 2 minutes, and then the animals will receive by intravenous boluses: Group 1: ADR (45µg/kg); Group 2: TP (20µg/kg) and Group 3: TP (20µg/kg) + ADR (45µg/kg), and BLS-CPR will be maintained for additional 2 minutes. Then (at the 14th minute FV), external defibrillation attempts will be carried through with DC shocks, until the return of the spontaneous circulation or the release of 5 DC shocks, according to the AHA advanced cardiac life support (ACLS) CPR. The surviving animals will be observed for an additional 30 minutes period, thus being sacrificed. Continuous recordings of the electrocardiogram, systemic arterial blood pressure, central venous pressure and end-tidal CO2 will be taken during the experiment. Arterial and central venous blood samples will be drawn for gas analysis at the following moments: before the induction of VF; at the end of the 10th min of unassisted VF; at the end of the 2nd min of BLS; just before de 1st DC shock and at the 10th min, 20th min and 30th min after CPR beginning. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ANA CAROLINA LONGUI MACEDO; LUIZ CLAUDIO MARTINS; ILMA APARECIDA PASCHOAL; CARLOS CESAR IVO SANT'ANA OVALLE; SEBASTIÃO ARAÚJO; MARCOS MELLO MOREIRA. PetCO(2), VCO2 and CorPP Values in the Successful Prediction of the Return of Spontaneous Circulation: An Experimental Study on Unassisted Induced Cardiopulmonary Arrest. Revista Brasileira de Cirurgia Cardiovascular, v. 31, n. 6, p. 468-473, Dez. 2016. (07/08315-0)

ANA CAROLINA LONGUI MACEDO; LUIZ CLAUDIO MARTINS; ILMA APARECIDA PASCHOAL; CARLOS CESAR IVO SANT'ANA OVALLE; SEBASTIÃO ARAÚJO; MARCOS MELLO MOREIRA. PetCO2, VCO2 and CorPP Values in the Successful Prediction of the Return of Spontaneous Circulation: An Experimental Study on Unassisted Induced Cardiopulmonary Arrest. Revista Brasileira de Cirurgia Cardiovascular, v. 31, n. 6, p. 468-473, 2016-12-00. (07/08315-0)

IVO SANT'ANA OVALLE, CARLOS CEZAR; MOREIRA, MARCOS MELLO; MARTINS, LUIZ CLAUDIO; ARAUJO, SEBASTIAO. The Efficacy of Terlipressin versus Adrenaline in Swine Cardiopulmonary Resuscitation. Revista Brasileira de Anestesiologia, v. 61, n. 6, p. 728-735, NOV-DEC 2011. (07/08315-0)