Polymorphism of COX-2 (-765 G>C) and 5-LOX G-1708A) in colorectal cancer patients

• Grant number: 09/14388-5
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2009
• End date: September 30, 2011
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Nora Manoukian Forones
• Grantee: Nora Manoukian Forones
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Colorectal cancer represents a major cause of death from cancer worldwide. Numerous genetic alterations have been associated with increased risk and aggressiveness of the cancer. The genes of cyclooxygenase and lipoxygenase are being studied act in cell cycle regulation, in tumor growth factor and production of prostaglandins. There are three isoforms of cyclooxygenase and lipoxygenase, and COX-2 and 5 - lipoxygenase those most involved in the process of tumor development and particularly colorectal cancer. The objective of this study is to evaluate the polymorphism of cyclooxygenase -2 promoter region 765G> C and 5-lipoxygenase (1708 G> A) in samples of peripheral blood and tumor tissue of patients with colorectal cancer. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MARQUES PIMENTA, CELIA APARECIDA; MOREIRA LATINI, FLAVIA ROCHE; DE LIMA, JACQUELINE MIRANDA; DA SILVA, TIAGO DONIZETTI; FELIPE, ALEDSON VITOR; DE LIMA PAZINE, VANESSA MARIA; FORONES, NORA MANOUKIAN. Study of the polymorphisms of cyclooxygenase-2 (-765G > C) and 5-lipoxygenase ( 1708G > A) in patients with colorectal cancer. Oncology Letters, v. 7, n. 2, p. 513-518, FEB 2014. (09/14388-5)