Study of the genetic polymorphism N-acetyiltranspherase and the sucetibility of colorectal cancer in Brazilians in the region of São Paulo

• Grant number: 08/05812-5
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2008
• End date: August 31, 2010
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Nora Manoukian Forones
• Grantee: Nora Manoukian Forones
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

The N-acetyltransferase 2 (NAT2) is an important enzyme of phase II, whose acetylation catalyst heterocyclic aromatic amines (HAA) and nitrosamines, found respectively in compounds carcinogens and therapeutic drugs (Edyta et al, 2006). Individuals with the NAT2 genotype of rapid acetylation may have larger amounts of metabolic activators of the HAA than individuals with low NAT2 acetylation and metabolic activators can be transmitted to the tissues through the bloodstream colorectal adducts causing mutation in the DNA and suppressor genes tumour that are involved in the formation of colorectal cancer (Pistorius et al, 2005). The association between the genetic polymorphism in the gene NAT2 and colorectal cancer has been studied extensively, however, has not yet conclusive results, and ethnic differences, lifestyle, number of patients, some of the causes of the variations found. The proportion of people with phenotype of fast and slow acetylation varies considerably depending on ethnicity and geographic origin (Garte et al, 2001). Thus it is needed to investigate the distribution of the frequency of NAT2 genotypes and the association of its polymorphism with colorectal cancer in the population of the city of Sao Paulo. (AU)