Implementation of a reference laboratory for the measurement of serum 25 hydroxy vitamin D (25OHD)

• Grant number: 08/04779-4
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2008
• End date: July 31, 2011
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: José Gilberto Henriques Vieira
• Grantee: José Gilberto Henriques Vieira
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

The project aims the installation of a reference laboratory for the measurement of 25-Hydroxyvitamin D (25OHD). 25OHD is the vitamin D metabolite that best represents sufficiency/insufficiency of this vitamin. Vitamin D deficiency is being appointed as a very prevalent problem in a series of populations, including Brazilian populations. The diagnosis of this condition, specially in old populations and patients with end stage renal disease, as well as its follow-up, is of paramount importance. Current methodologies for the measurement of 25OHD present problems of reproducibility and accuracy, as well as cost. The availability of a refence laboratory capable of measuring 25OHD by a reference method (HPLC-UV) would be of interest for the scientific and medical community. (AU)