Dynamic analysis of renal function and morphology in rats with acute kidney injury

• Grant number: 08/04846-3
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2008
• End date: September 30, 2010
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Júlio César Martins Monte
• Grantee: Júlio César Martins Monte
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Acute kidney injury (AKI) remains a common clinical problem with serious consequences and unsastifactory therapeutic options. One of the reasons for the lack of success in clinical trials of AKI include difficulty in timely administration of the drug to prevent or treat AKI. Once AKI is established, we must rely on serial measurements of creatinine as an indicator of renal function. The rise in serum creatinine is slow after kidney injury. By the time a change is observed in serum creatinine, a critical therapeutic window may been missed. Because of this, a mathematical model for study the dynamics of renal failure has been proposed recently. This dynamic model used an ordinary differential equation based on production and filtration to model the temporal changes of creatinine during AKI and recovery. The authors hypothetize that their model can identify the end of deterioration and the onset of recovery after AKI. However, tubular damage after injury and their relative contribuition to the evolving renal disfunction has not been established. In addition to morphological changes throughout renal disfunction we aim to validate the model by measurements of glomerular filtration using clearance of inulin. (AU)