| Grant number: | 10/51654-2 |
| Support Opportunities: | Regular Research Grants |
| Start date: | October 01, 2010 |
| End date: | March 31, 2013 |
| Field of knowledge: | Agronomical Sciences - Veterinary Medicine - Animal Reproduction |
| Principal Investigator: | José Antonio Visintin |
| Grantee: | José Antonio Visintin |
| Host Institution: | Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
Abstract
Mammalian spermatogenesis is a classic adult stem cell-dependent process, sustained by self renewal and differentiation of spermatogonial stem cells (SSCs). Studying SSCs provides a model to better understand adult stem cell biology and decipher the mechanisms that control SSC functions. It was reported that these cells hold the ability to colonize the seminiferous tubule after transplantation, restoring spermatogenesis. Besides the biomedical potential to perform studies of infertility in many species, SSCs present a promising application at biotechnology in order to produce transgenic animals. In this manner, the objectives of this study are to isolate, characterize, genetically modify and transplant murine and bovine SSCs, in order to reach a better knowledge of the ex vivo and in vitro behavior of these cells and establish a new tool for transgenesis. (AU)
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