Profile of the intra-ocular pressure in the water-drinking test with different volumes of water intake

• Grant number: 10/12592-1
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2010
• End date: September 30, 2011
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Remo Susanna Junior
• Grantee: Remo Susanna Junior
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Alexandre Soares Castro Reis ; Jayme Augusto Rocha Vianna

Abstract

The intra-ocular pressure (IOP) is the main risk factor for development and progression of glaucoma. The Water-Drinking Test (WDT) is a stress test used to evaluate how an eye can deal with transitory increases of the IOP. This study has the purpose of determinate, during the WDT, the influence of different volumes of water intake in determining the fluctuation and peak of IOP with Goldman tonometry in patients with primary open-angle glaucoma (POAG). It is relevant because there is no standard volume of water intake, and a possibility to reduce this volume. 35 patients will be selected from the Glaucoma Department for presenting optic nerve and/or visual field signs typical of POAG. These patients will perform the WDT in two different days, with volumes of 1L and 650mL, in the same hour. For the test, they should fast for 4 hours, measure the baseline IPO, drink the amount of water in 10 minutes, and have new measurements after 15, 30 and 45 minutes. The statistical analysis will have comparisons and correlations between the pressure levels obtained with different volumes. (AU)