Development and nationalization of the technology for the manufacture of Clonazepam

• Grant number: 02/07839-1
• Support Opportunities: Research Grants - Innovative Research in Small Business - PIPE
• Start date: April 01, 2003
• End date: November 30, 2003
• Field of knowledge: Engineering - Chemical Engineering - Chemical Technology
• Principal Investigator: William Carnicelli
• Grantee: William Carnicelli
• Company: Alpha Produtos Químicos Ltda
• City: São Paulo

Abstract

The aim of the proposed project is the development of technology for nationalization of the manufacture of Clonazepam, a product used in the pharmaceutical industry in the preparation of anticonvulsive medicines consumed by patients who have neurological problems, principally epilepsy. The main manufacturer of these medicines is a multinational company which practically supplies the whole market with this specialty in Brazil. The local manufacture of Clonazepam will enable it to be offered to national laboratories, in general large manufacturers of generic medicines and the like, such as União Química, EMS, Sanval, Medley and Teuto, among others. The product to be developed will meet the quality standards of Brazilian, American, European and Japanese pharmacopoeia, allowing therefore for its export, principally to Mercosul countries. In its first phase, the project will conduct a research and development study into the best route for synthesizing Clonazepam on a laboratory scale, followed by its development on a scale of 20 liters. The next stage will be work on a 250 liter pilot plant, now in the pre-industrial phase. (AU)