Study of the in vitro and in vivo effects of fatty acids on mitochondrial morphology and fatty acid composition and the relationship of these factors to the control of energy producing [... ]

• Grant number: 96/10378-3
• Support Opportunities: Research Grants - Young Investigators Grants
• Start date: April 01, 1997
• End date: September 30, 2001
• Field of knowledge: Biological Sciences - Biochemistry - Metabolism and Bioenergetics
• Principal Investigator: Alison Colquhoun
• Grantee: Alison Colquhoun
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant(s): 98/05626-3 - Acyl coa hydrolase activity of the walker 256 tumour and its alteration by dietary supplementation., AR.EXT
• Associated scholarship(s): 97/02853-6 - Study of the in vitro and in vivo effects of fatty acids on mitochondrial morphology and fatty acid composition and the relationship of these factors to the control of energy of producing, BP.JP

Abstract

Fatty acid regulation of energy producing pathways will be linked to morphological changes in mitochondrial with the aim to determine how control of tumour energy metabolism by fatty acids is related to morphology. Focus will be on how fatty acids are partitioned between oxidative and biosynthetic processes and whether carnitine palmitoyltransferase it is involved in this partitioning. Changes in fatty acid composition of cellular components will be related to changes in cellular and mitochondrial morphology and to CPT I activity and malonyl CoA sensitivity. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RAMOS‚ K.L.; COLQUHOUN‚ A.. Protective role of glucose-6-phosphate dehydrogenase activity in the metabolic response of C6 rat glioma cells to polyunsaturated fatty acid exposure. Glia, v. 43, n. 2, p. 149-166, 2003. (96/10378-3, 97/02853-6)