In vitro and in vivo evaluation of nineteen molecules with high anti-inflammatory potential

• Grant number: 98/04673-8
• Support Opportunities: Research Grants - Research Partnership for Technological Innovation - PITE
• Start date: December 01, 1998
• End date: March 31, 2006
• Field of knowledge: Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
• Principal Investigator: Gilberto de Nucci
• Grantee: Gilberto de Nucci
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Company: Aché Laboratórios Farmacêuticos S/A (ACHÉ)
• City: São Paulo

Abstract

The project aimed to evaluate in vitro and in vivo laboratory synthesized molecules, with anti-inflammatory action, leading from there to new medicines. The in vitro evaluation was carried out, on the one hand, through the contact of the synthesized molecules with the cyclooxygenase enzyme, present in all inflammatory processes. Tests were carried out on platelets of human blood. The in vivo tests were carried out on mice. One of the synthesized molecules displayed positive results in all the in vitro and in vivo tests. (AU)