Participation of beta-adrenoceptors in the contraction of rat renal and femoral veins induced by sympathomimetic agonists

• Grant number: 11/02097-6
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2011
• End date: July 31, 2013
• Field of knowledge: Biological Sciences - Pharmacology - Cardiorenal Pharmacology
• Principal Investigator: Agnaldo Bruno Chies
• Grantee: Agnaldo Bruno Chies
• Host Institution: Faculdade de Medicina de Marília (FAMEMA). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). Marília , SP, Brazil
• Associated researchers: Patrícia de Souza Rossignoli

Abstract

The venous bed is considered the major reservoir of blood in the body since about 60-80% of the blood of mammals is in this compartment during the rest. Because of this, it has a key role in the regulating of blood volume that reaches into the heart. On the other hand, although the venous bed exerts a key role in circulatory homeostasis, the mechanisms involved in regulating the tone of the veins are complex and still poorly understood. Several studies have suggested that the responses of veins to adrenergic stimulation may vary depending on territory. Among the reasons for these territory-specific variations of response, we can point the heterogeneous distribution of pharmacological receptors along the venous path. Regarding to the beta-adrenergic receptors, there are differences not only related to its distribution but also in relation to the effects mediated by them. In fact, there are evidences in the literature suggesting that beta-adrenoceptor mediates venoconstriction in certain parts of the venous bed, which contrasts with the arterial bed where these receptors usually induce vasodilation. Recently, we found that noradrenaline, a non-selective beta-adrenoceptor agonist, induces venoconstriction in renal vein of rats much higher in comparison with phenylephrine, a selective agonist of alfa-adrenoceptors. Thus, considering the relevance to better understand the mechanisms that control the venous tone, we proposed the present research project whose goal is to investigate the involvement of beta-adrenoceptors in the contractile responses of rat renal and femoral veins induced by sympathomimetic agonists. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ROSSIGNOLI, PATRICIA DE SOUZA; YAMAMOTO, FERNANDA ZOCATELLI; MARQUES PEREIRA, ODUVALDO CAMARA; CHIES, AGNALDO BRUNO. Norepinephrine responses in rat renal and femoral veins are reinforced by vasoconstrictor prostanoids. VASCULAR PHARMACOLOGY, v. 72, p. 93-100, SEP 2015. (11/02097-6)