Association between traditional, novel and uremic related risk factors and morbidity/mortality (all-cause and cardiovascular) in chronic kidney disease patients

• Grant number: 10/16593-2
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2011
• End date: July 31, 2013
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Antonio Carlos Cordeiro Silva Júnior
• Grantee: Antonio Carlos Cordeiro Silva Júnior
• Host Institution: Instituto Dante Pazzanese de Cardiologia (IDPC). Fundação Adib Jatene (FAJ). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Adriana Regina Garofalo ; Amanda Guerra de Moraes Rego Souza ; Celso Amodeo ; Fernanda Cassullo Amparo ; Hui Tzu Lin Wang ; Mario Hiroyuki Hirata ; Simone Sorkin Arazi

Abstract

The mortality of patients with Chronic Kidney Disease (CKD), even after adjustment for traditional risk factors, is 10 to 20 times greater than the general population, mainly as a consequence of cardiovascular disease (CVD). The chronic inflammatory state is one of the most important nontraditional risk factors for general and cardiovascular mortality. The relationship between CKD and inflammation is established since the early stages of renal disease. Inflammation is a recognized causal factor for the development and acceleration of atherosclerotic disease. Inflammatory biomarkers, such as interleucin-6 (IL-6) and C-reactive protein (CRP) are associated with atherosclerosis and mortality in CKD patients. Furthermore, the association between inflammation, oxidative stress and protein-energy wasting seems to have a synergistic effect in the development of accelerated atherosclerosis in CKD patients.Coronary arteries calcification is present in almost exclusively in coronary artery disease (CAD); however in CKD patients are one exception, since these patients could present media (non-atherosclerotic) calcification. Therefore in CKD the association between coronary calcification and CAD is not clear, and the value of calcium score as a predictor of cardiac events is not fully established. Specific aims: To evaluate the association between inflammatory and nutritional parameters as well as the coronary calcium score with the morbimortality (all-cause and cardiovascular) in patients with chronic kidney disease. (AU)

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

AMPARO, FERNANDA C.; KAMIMURA, MARIA A.; MOLNAR, MIKLOS Z.; CUPPARI, LILIAN; LINDHOLM, BENGT; AMODEO, CELSO; CARRERO, JUAN J.; CORDEIRO, ANTONIO C.. Diagnostic validation and prognostic significance of the Malnutrition-Inflammation Score in nondialyzed chronic kidney disease patients. Nephrology Dialysis Transplantation, v. 30, n. 5, p. 821-828, MAY 2015. (10/16593-2)

CORDEIRO, A. C.; AMPARO, F. C.; OLIVEIRA, M. A. C.; AMODEO, C.; SMANIO, P.; PINTO, I. M. F.; LINDHOLM, B.; STENVINKEL, P.; CARRERO, J. J.. Epicardial fat accumulation, cardiometabolic profile and cardiovascular events in patients with stages 3-5 chronic kidney disease. JOURNAL OF INTERNAL MEDICINE, v. 278, n. 1, p. 77-87, JUL 2015. (10/16593-2)

GIGLIO, JULIANA; KAMIMURA, MARIA AYAKO; SOUZA, NILIAN CARLA; BICHELS, ANDRE VALENTE; CORDEIRO, ANTONIO CARLOS; PINHO, NIVALDO; AVESANI, CARLA MARIA. Muscle mass assessment by computed tomography in chronic kidney disease patients: agreement with surrogate methods. European Journal of Clinical Nutrition, v. 73, n. 1, p. 46-53, JAN 2019. (10/16593-2)

CORDEIRO, ANTONIO C.; LINDHOLM, BENGT; SOUSA, MARCIO G.; PICOTTI, JULIANO C.; NUNES, GABRIEL J.; SANTANA, MARCUS R. O.; GRIMALDI, JR., WALDYR; AMPARO, FERNANDA C.; AMODEO, CELSO; CARRERO, JUAN J.. Reliability of electrocardiographic surrogates of left ventricular mass in patients with chronic kidney disease. Journal of Hypertension, v. 32, n. 2, p. 439-445, FEB 2014. (10/16593-2)

CORDEIRO, ANTONIO C.; MORAES, ALINE A. I.; CERUTTI, VIRGINIA; FRANCA, FAUSTINO; QUIROGA, BORJA; AMODEO, CELSO; PICOTTI, JULIANO C.; DUTRA, LUCAS V.; RODRIGUES, GABRIEL D.; AMPARO, FEMANDA C.; et al. Clinical determinants and prognostic significance of the electrocardiographic strain pattern in chronic kidney disease patients. JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION, v. 8, n. 5, p. 312-320, MAY 2014. (10/16593-2)

CORDEIRO, ANTONIO CARLOS; QURESHI, ABDUL RASHID; LINDHOLM, BENGT; AMPARO, FERNANDA CASSULLO; TITO-PALADINO-FILHO, ANTONIO; PERINI, MARCELA; LOURENCO, FERNANDA SILVESTRE; FRANCISCO PINTO, IBRAIM MASCIARELLI; AMODEO, CELSO; CARRERO, JUAN JESUS. Visceral fat and coronary artery calcification in patients with chronic kidney disease. Nephrology Dialysis Transplantation, v. 28, n. 4, p. 152-159, NOV 2013. (10/16593-2)

AMPARO, FERNANDA C.; CORDEIRO, ANTONIO C.; CARRERO, JUAN J.; CUPPARI, LILIAN; LINDHOLM, BENGT; AMODEO, CELSO; KAMIMURA, MARIA A.. Malnutrition-Inflammation Score is Associated With Handgrip Strength in Nondialysis-Dependent Chronic Kidney Disease Patients. JOURNAL OF RENAL NUTRITION, v. 23, n. 4, p. 283-287, JUL 2013. (10/16593-2)

MOLNAR, MIKLOS Z.; CARRERO, JUAN J.; MUCSI, ISTVAN; REMPORT, ADAM; RHEE, CONNIE M.; KALANTAR-ZADEH, KAMYAR; KOVESDY, CSABA P.; CORDEIRO, ANTONIO C.. Comparison of the malnutrition-inflammation score in chronic kidney disease patients and kidney transplant recipients. INTERNATIONAL UROLOGY AND NEPHROLOGY, v. 47, n. 6, p. 1025-1033, JUN 2015. (10/16593-2)

CORDEIRO, ANTONIO CARLOS; QURESHI, ABDUL RASHID; LINDHOLM, BENGT; AMPARO, FERNANDA CASSULLO; TITO-PALADINO-FILHO, ANTONIO; PERINI, MARCELA; LOURENCO, FERNANDA SILVESTRE; FRANCISCO PINTO, IBRAIM MASCIARELLI; AMODEO, CELSO; CARRERO, JUAN JESUS. Visceral fat and coronary artery calcification in patients with chronic kidney disease. Nephrology Dialysis Transplantation, v. 28, p. 8-pg., 2013-11-01. (10/16593-2)