Immunoprofile of basal cell adenoma (emphasizing its relationship with the intercalated duct lesion) and myoepithelial cells (influenced by factors of tumor microenvironment)

• Grant number: 11/51112-8
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2011
• End date: August 31, 2013
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Albina Messias de Almeida Milani Altemani
• Grantee: Albina Messias de Almeida Milani Altemani
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The salivary lesions, which are considered as originated from the intercalated duct are composed of two cell populations (epithelial and myoepithelial). These lesions are classified in different entities which show morphological overlapping. Pleomorphic adenoma (PA) and Basal cell adenoma (BCA) are among the benign neoplasias. Recently, a new benign tumoral entity named intercalated duct lesion (IDL) was described, which is composed by epithelial and myoepithelial cells as well. The morphological overlapping between BCAs and IDLs, in addition to the fact that immunoprofile of BCAs has yet to be better explored, led us to study this lesion and its possible relationship with IDLs. Given the critical role of myoepithelial cells in the morphogenesis of lesions related to the intercalated duct, the second objective of the present study is to broad our knowledge on the factors that influencing the immunophenotype and secretion of these cells. Regarding to the first objective, 25 ACBs and 8 IDLs will be studied using a panel of monoclonal antibodies; the positivity will be quantitative and qualitatively analyzed and compared with the normal intercalated ducts. Concerning to the second, the influence of different proteins of the extra-cellular matrix (matrigel, collagen I and fibronectin) as well as the growth factors (EGF and TGF-beta) involved in the tumorigenesis will be analyzed by in vitro study. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MONTALLI, VICTOR ANGELO; MARTINEZ, ELIZABETH; TINCANI, ALFIO; MARTINS, ANTONIO; ABREU, MARIA DO CARMO; NEVES, CATARINA; COSTA, ANA FLAVIA; DE ARAUJO, VERA C.; ALTEMANI, ALBINA. Tubular variant of basal cell adenoma shares immunophenotypical features with normal intercalated ducts and is closely related to intercalated duct lesions of salivary gland. Histopathology, v. 64, n. 6, p. 880-889, MAY 2014. (11/51112-8, 11/10366-7)