DHMEQ effect on ex-vivo cultures of nasal polyps

• Grant number: 11/19140-1
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2011
• End date: November 30, 2013
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Fabiana Cardoso Pereira Valera
• Grantee: Fabiana Cardoso Pereira Valera
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

DHMEQ is a NF-kappa B inhibitor with a potent anti-inflammatory and anti-neoplastic effect. The topical nasal use of this drug would in theory be an important therapeutical task, especially in patients refractory to topical corticosteroids. The anti-inflammatory effect of DHMEQ has been confirmed in arthritis, atopic dermatitis and even septic toxemia. In nasal polyps, previous studies in our center have confirmed the inhibition of inflammatory induction in nasal fibroblasts cultures. Nevertheless, further studies are highly recommended prior to in vivo studies. in this project, we aim to evaluate if DHMEQ can inhibit the inflammatory process in ex vivo nasal polyps cultures (AU)