Process for the obtaining, composition and use of a system of recombinant hormones for superovulation in vertebrates

• Grant number: 03/13214-7
• Support Opportunities: Research Grants - Innovative Research in Small Business - PIPE
• Start date: September 01, 2004
• End date: May 31, 2005
• Field of knowledge: Biological Sciences - Genetics - Animal Genetics
• Principal Investigator: Jorge Luiz Pesquero
• Grantee: Jorge Luiz Pesquero
• Company: Proteobrás Desenvolvimento Biotecnológico Ltda

Abstract

The present proposal aims to establish in the city of Mogi das Cruzes a company specialized in the production of biotechnologies, specifically proteins for application in laboratories carrying out research, both in human health and in the veterinary field, with emphasis on the use of genetic recombination. It is intended, for this purpose, to establish a structure for the manipulation of genes of different animals. These genes should be introduced in specific vectors and these vectors inserted into genome cells or microorganisms which, in the process of fermentation, will proceed to express the respective gene, in this way producing the desired protein. It is also intended to establish the entire structure of the test of biological activity for these products and, in aseptic conditions, prepare for their use in animals and/or humans. The group has been working for years in this field, having produced proteins of high economic potential, for example: bovine and equine follicle-stimulating hormone (FSH), activin, inhibin and proteins homologous to angiostatins. Based on the angiostatin sequence, the group cloned and expressed a variety of this protein and proved its antitumoral effectiveness in experiments involving different animal species. (AU)