Studying the effects of administration of polyunsaturated fatty acids (PUFAs) of omega-3 series in nicotine dependence

• Grant number: 12/06731-4
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2012
• End date: January 31, 2015
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Principal Investigator: José Carlos Fernandes Galduroz
• Grantee: José Carlos Fernandes Galduroz
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated researchers: Juçara Xavier Zaparoli

Abstract

A cigarette has more than 6,000 toxic substances that can cause various diseases. Nicotine dependence may prolong the exposure to these toxic substances. The Central Nervous System (CNS) is consisted by a large amount of Polyunsaturated Fatty Acids (PUFAS) from omega-3 serie. Omega-3 takes part in several actions, including the modulation of dopaminergic neurotransmission. In its deficiency is detected a hypofunctioning of the mesolimbic and mesocortical pathway, related to the reward system, involved on the context of nicotine dependence. Treatment using dietary supplementation with omega-3 shows improvements in several diseases, including mood disorders such as anxiety and depression. The supplementation with these fatty acids can restore the levels of omega-3 and could decrease nicotine dependence. Objective: Investigate a possible association between increased serum levels of omega-3 and the reduction in nicotine dependence. Material and Methods: In the clinical study, placebo controlled, double-blind, parallel, randomized, will be administered to 60 volunteers: placebo or fish oil for 90 days. Psychometric assessments will be carried out, measurements of serum levels of PUFAS, levels of carbon monoxide (CO) and cotinine in plasma will be done for monitoring the clinical course. Data Analysis: Repeated measures (ANOVA) for the dependent variables (dependency, anxiety, depression, motivation, compulsion, dosage of PUFAS, exhaled CO and cotinine) and independent (groups and time) to check for significant differences. If so, a second ANOVA with covariates will be conducted. Significance is p <0.05 in all analyzes. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ZAPAROLI, JUCARA X.; SUGAWARA, EDUARDO K.; DE SOUZA, ALTAY A. L.; TUFIK, SERGIO; GALDUROZ, JOSE CARLOS F.. Omega-3 Levels and Nicotine Dependence: A Cross-Sectional Study and Clinical Trial. EUROPEAN ADDICTION RESEARCH, v. 22, n. 3, p. 153-162, 2016. (15/17708-1, 12/06731-4)

PRIOR, PEDRO LUIS; VAZ, MARTA JEZIERSKI; RAMOS, ANNA CAROLINA; FERNANDES GALDUROZ, JOSE CARLOS. Influence of Microelement Concentration on the Intensity of Alcohol Withdrawal Syndrome. ALCOHOL AND ALCOHOLISM, v. 50, n. 2, p. 152-156, MAR-APR 2015. (12/06731-4)