| Grant number: | 12/10321-6 |
| Support Opportunities: | Regular Research Grants |
| Start date: | September 01, 2012 |
| End date: | August 31, 2014 |
| Field of knowledge: | Health Sciences - Medicine - Medical Clinics |
| Principal Investigator: | Eny Maria Goloni Bertollo |
| Grantee: | Eny Maria Goloni Bertollo |
| Host Institution: | Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil |
Abstract
Hepatocellular carcinoma (HCC) is a primary liver cancer and occurs on more than 80% of cases of liver cancer. Median survival is about 23 months and its staging is based on histopathological features. Etiology of HCC is due to many factors, but its major cause is liver cirrhosis. This tumor secretes vascular endothelial growth factor, so angiogenesis is involved on its formation process, as well as high expression of VEGF gene, that has its process regulated by microRNA (miR, miRNA), that are single-stranded, about 22 nucleotides length and role on silencing or activating transcript gene mRNA. This project aims to analyze the relationship of miRNAs that have VEGF gene as a target and its expression on HCC. Epigenetics studies can generate new discoveries, facilitate diagnosis and lead to appearance of new treatment, like miRNA therapy and improvement of currently used therapies, which will raise survival and consequently raise cure possibilities. (AU)
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