Immune and antiviral response in central nervous system of mice experimentally infected with rabies virus strains isolated from different species

• Grant number: 12/00895-5
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2012
• End date: August 31, 2014
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Preventive Veterinary Medicine
• Principal Investigator: Jane Megid
• Grantee: Jane Megid
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Rabies control is considered a worldwide challenge. Different virus strains (RABV) are isolated from different species, they have distinct immunogenic characteristics as well in their nucleotides sequence, allowing their classification into variants and genotypes. Furthermore, differences in pathogenicity have also been observed through experimental inoculation in mice and cell cultures. The mechanisms by which RABV infects an individual and perpetuated the infection in nature have not been fully clarified. However some factors that lead to successful infection are already established, among the most important we can mention the ability to induce apoptosis of T cells and maintain the integrity and functionality of neurons. These events are mediated by cytokines that regulate several genes involved in this complex process still poorly understood. Considering the diversity of viral strains circulating and the complexity of events involved in the neuroinvasiveness of RABV this project aims to study the gene expression pathway, immune response and pathogenicity of different virus strain by means of experimental inoculation in mice. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

APPOLINARIO, CAMILA; ALLENDORF, SUSAN DORA; VICENTE, ACACIA FERREIRA; RIBEIRO, BRUNA DEVIDE; DA FONSECA, CLOVIS REINALDO; ANTUNES, JOAO MARCELO; PERES, MARINA GEA; KOTAIT, IVANETE; CARRIERI, MARIA LUIZA; MEGID, JANE. Fluorescent antibody test, quantitative polymerase chain reaction pattern and clinical aspects of rabies virus strains isolated from main reservoirs in Brazil. Brazilian Journal of Infectious Diseases, v. 19, n. 5, p. 479-485, SEP-OCT 2015. (12/00896-1, 12/00895-5)