Analysis of CCR5-dependent Regulatory T cell migration: correlation with SCC development

• Grant number: 12/15331-0
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2012
• End date: October 31, 2014
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Ana Paula Campanelli
• Grantee: Ana Paula Campanelli
• Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil

Abstract

Squamous cell carcinoma (OSCC) is a cancerous lesion with high incidence worldwide. The immunoregulatory events leading to SCC development remain to be elucidated. Our group show that regulatory T cells (Tregs) are important to obstruct antitumor immune responses in patients with OSCC. The migration of Tregs cells to the tumor microenviromment is an important mechanism to promote the local suppression of the effector immune response. Indeed, chemokines such CCL3, CCL4, CCL17, and CCL22, produced in inflammatory tissues, lead to the accumulation of CCR4+ and CCR5+ regulatory T cells in peripheral sites. CCL4 is a ligand of CCR5 and the most potent chemoattractant of Treg cells. Because regulatory T cells are in the lesions of SCC and the migration of Treg cells is dependent on the axis chemokine-chemokine receptors, we investigated the role of CCR5 during SCC development. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE OLIVEIRA, CARINE ERVOLINO; GASPAROTO, THAIS HELENA; PINHEIRO, CLAUDIA RAMOS; AMOR, NADIA GHINELLI; SALES NOGUEIRA, MARIA RENATA; KANENO, RAMON; GARLET, GUSTAVO POMPERMAIER; LARA, VANESSA SOARES; SILVA, JOAO SANTANA; CAVASSANI, KAREN ANGELICA; et al. CCR5-Dependent Homing of T Regulatory Cells to the Tumor Microenvironment Contributes to Skin Squamous Cell Carcinoma Development. MOLECULAR CANCER THERAPEUTICS, v. 16, n. 12, p. 2871-2880, DEC 2017. (12/15331-0)

GASPAROTO, THAIS HELENA; DE OLIVEIRA, CARINE ERVOLINO; DE FREITAS, LUISA THOMAZINI; PINHEIRO, CLAUDIA RAMOS; HORI, JULIANA ISSA; GARLET, GUSTAVO POMPERMAIER; CAVASSANI, KAREN ANGELICA; SCHILLACI, ROXANA; DA SILVA, JOAO SANTANA; ZAMBONI, DARIO SIMOES; et al. Inflammasome Activation Is Critical to the Protective Immune Response during Chemically Induced Squamous Cell Carcinoma. PLoS One, v. 9, n. 9, SEP 30 2014. (11/09664-3, 09/14127-7, 12/15331-0, 11/03195-1)