Oxybutynin effectiveness in women with persistent plantar hyperhidrosis after thoracoscopic sympathectomy

• Grant number: 12/18367-5
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2013
• End date: March 31, 2015
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Luiz Eduardo Villaça Leão
• Grantee: Luiz Eduardo Villaça Leão
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated researchers: Altair da Silva Costa Júnior

Abstract

Hyperhidrosis is a relatively common disease and affects up to 1% of the population. The thoracoscopic sympathectomy improves the symptoms by 80 to 95%. The plantar hyperhidrosis may remain even after surgery in approximately 50% of patients and the compensatory sweating in almost 70%. Our objective is to evaluate the effectiveness of oxybutynin in the treatment of persistent plantar hyperhidrosis and quality of life in women who had already undergone thoracic sympathectomy. Method: We will conduct a prospective randomized study to compare oxybutynin, 10 mg daily, with placebo. Factors include: women with persistent plantar hyperhidrosis with limited their usual activities, body mass index <25 kg/m2, age between 18 and 40 years old. We will do the evaluation through questionnaires on quality of life for hyperhidrosis, a specific questionnaire for plantar hyperhidrosis and compensatory sweating. The sweat will be measured with a device for quantifying transepidermal water loss by evaporation - "Vapometer®". (AU)