Effect of raloxifene on periapical lesions in ovariectomized rats

• Grant number: 12/06943-1
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2013
• End date: April 30, 2015
• Field of knowledge: Health Sciences - Dentistry - Endodontics
• Principal Investigator: João Eduardo Gomes Filho
• Grantee: João Eduardo Gomes Filho
• Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil
• Associated researchers: Edilson Ervolino ; Rita Cássia Menegati Dornelles

Abstract

Considering the oral health must be understood as integral and inseparable part of the individual overall health, studies about periapical lesions in osteopenic bodies are needed for information and understanding of the mechanisms that may be involved in this interaction. With advancing age, the lower production and secretion of estradiol contribute to decreased bone tissue associated with menopause, resulting in osteopenia and osteoporosis, which can be prevented with the implementation of hormone replacement therapy. In this experimental study will be used raloxifene, selective modulator of estrogen receptor, with selective agonist activity (on the bone tissue and cardiovascular) and antagonist (on the breast and uterus), reducing the side effects triggered by hormone replacement therapy. The aim of this study will be analyze and compare the periapical lesion, the concentrations of cellular activity markers of bone metabolism as well as analysis of protein expression OPG, RANK,RANKL, TRAP and HIF1-alpha as cellular markers of predisposition to resorption or formation of tissue bone in adult female rats (06 months) sham ovariectomized and treated or not with raloxifene. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

HOLLAND, ROBERTO; GOMES FILHO, JOAO EDUARDO; ANGELO CINTRA, LUCIANO TAVARES; DE AZEVEDO QUEIROZ, INDIA OLINTA; ESTRELA, CARLOS. Factors affecting the periapical healing process of endodontically treated teeth. Journal of Applied Oral Science, v. 25, n. 5, p. 465-476, SEP-OCT 2017. (12/09987-0, 12/02083-8, 12/01153-2, 12/06785-7, 12/06943-1)

GOMES-FILHO, J. E.; WAYAMA, M. T.; DORNELLES, R. C. M.; ERVOLINO, E.; YAMANARI, G. H.; LODI, C. S.; SIVIERI-ARAUJO, G.; DEZAN-JUNIOR, E.; CINTRA, L. T. A.. Raloxifene modulates regulators of osteoclastogenesis and angiogenesis in an oestrogen deficiency periapical lesion model. International Endodontic Journal, v. 48, n. 11, p. 1059-1068, NOV 2015. (12/05232-4, 12/06943-1)

HOLLAND, ROBERTO; GOMES FILHO, JOAO EDUARDO; ANGELO CINTRA, LUCIANO TAVARES; DE AZEVEDO QUEIROZ, INDIA OLINTA; ESTRELA, CARLOS. Factors affecting the periapical healing process of endodontically treated teeth. Journal of Applied Oral Science, v. 25, n. 5, p. 12-pg., 2017-09-01. (12/09987-0, 12/06785-7, 12/01153-2, 12/06943-1, 12/02083-8)