Regulation of gastric growth: the role of corticosterone, TGF alpha, EGFR and TGF beta

• Grant number: 05/01273-4
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2005
• End date: November 30, 2008
• Field of knowledge: Biological Sciences - Morphology - Histology
• Principal Investigator: Patrícia Gama
• Grantee: Patrícia Gama
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Milk, hormones and growth factors are essential for gastric growth. In the current study three proposals aim to evaluate the role of some elements on the postnatal development in models used in our laboratory. Proposal 1- Early weaning takes out milk factors from diet, stressing the pups in concomitant with high corticosterone and TGF alpha levels. In turn, TGF alpha stimulates cell proliferation and differentiation. Specific aims: a) localize and verify the activity of EGFR in the gastric mucosa of early weaned rats; b) evaluate whether the inhibition of EGFR changes the cell proliferation in this model. Proposal 2: During suckling phase, fasting stimulates gastric cell division, in contrast to the effect observed in adult rats, creating an important paradigm in the study of non-tumoral hyperproliferation. Fasting also promotes stress and increases corticosterone levels... (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

OGIAS, DANIELA; DE ANDRADE SA, EUNICE RIBEIRO; KASAI, ARIANE; MOISAN, MARIE-PIERRE; ALVARES, ELIANA PARISI; GAMA, PATRICIA. Fasting differentially regulates plasma corticosterone-binding globulin, glucocorticoid receptor, and cell cycle in the gastric mucosa of pups and adult rats. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, v. 298, n. 1, p. G117-G125, JAN 2010. (05/01273-4)

OSAKI, L. H.; FIGUEIREDO, P. M.; ALVARES, E. P.; GAMA, P.. EGFR is involved in control of gastric cell proliferation through activation of MAPK and Src signalling pathways in early-weaned rats. Cell Proliferation, v. 44, n. 2, p. 174-182, APR 2011. (05/01273-4)

OSAKI, LUCIANA H.; CURI, MARCO A. F.; ALVARES, ELIANA P.; GAMA, PATRICIA. Early weaning accelerates the differentiation of mucous neck cells in rat gastric mucosa: Possible role of TGF alpha/EGFR. DIFFERENTIATION, v. 79, n. 1, p. 48-56, JAN 2010. (05/01273-4, 07/05441-4)