Individual idiosyncrasy in the distribution of cortical electrical activity

• Grant number: 13/07236-0
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2014
• End date: January 31, 2016
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Luis Fernando Hindi Basile
• Grantee: Luis Fernando Hindi Basile
• Host Institution: Escola de Ciências Médicas e da Saúde. Universidade Metodista de São Paulo (UMESP). Instituto Metodista de Ensino Superior (IMS). São Bernardo do Campo , SP, Brazil

Abstract

The aim of this project is to establish quantitatively the individual idiosyncrasy in electrically active cortical areas as inherent to association cortical physiology and not due to experimental 'errors' in general. We requested an equipment and software upgrade to overcome technical limitations and attempt to replicate individual results, confirm the lack of important topographic changes in beta (and other forms of non-sensory-motor) activity across tasks within individuals, and perform an original inter-subject comparison without recurring to the questionable spatial grand averaging. We will compute cortical topographic similarity measures between subjects (paired by cerebral similarity), tasks and individual replication sessions. We predict significantly higher similarity, as measured by reciprocal multiple linear regression modeling between sets of beta (and other) cortical generators, in task-related topography within subjects (already demonstrated for attention and reasoning tasks by a simpler method, Basile et al., 2013 - attached), followed by sessions of the same subject, and lowest between pairs of subjects. If confirmed, our hypothesis will have fundamental implications to cortical physiology, such as the inexistence of predetermined functions of any given association area, and to the psychophysiology of task-related activity. In particular, it may serve as a basis for new procedures in Functional Neurosurgery. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BASILE, LUIS F. H.; SATO, JOAO R.; PASQUINI, HENRIQUE A.; VELASQUES, BRUNA; RIBEIRO, PEDRO; ANGHINAH, RENATO. Individual versus task differences in slow potential generators. NEUROLOGICAL SCIENCES, JAN 2021. (13/07236-0)

BASILE, LUIS F. H.; SATO, JOAO R.; PASQUINI, HENRIQUE A.; VELASQUES, BRUNA; RIBEIRO, PEDRO; ANGHINAH, RENATO. Higher similarity in beta topography between tasks than subjects. Brain Structure & Function, v. 223, n. 4, p. 1627-1635, MAY 2018. (13/07236-0)

BASILE, LUIS F. H.; SATO, JOAO R.; PASQUINI, HENRIQUE A.; VELASQUES, BRUNA; RIBEIRO, PEDRO; ANGHINAH, RENATO. Individual versus task differences in slow potential generators. NEUROLOGICAL SCIENCES, v. 42, n. 9, p. 3781-3789, SEP 2021. (13/07236-0)

BASILE, LUIS F. H.; SATO, JOAO R.; PASQUINI, HENRIQUE A.; LOZANO, MIRNA D.; NUCCI, MARIANA P.; VELASQUES, BRUNA; RIBEIRO, PEDRO; RAMOS, RENATO T.; ANGHINA, RENATO. Individual Topographic Variability Is Inherent to Cortical Physiology but Task-Related Differences May Be Noise. PLoS One, v. 10, n. 5, MAY 26 2015. (13/07236-0)