Biomecular profile of experimental malignant pleural effusion: frequency of mutations and targeted therapies impact

• Grant number: 13/11148-9
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2014
• End date: September 30, 2016
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Lisete Ribeiro Teixeira
• Grantee: Lisete Ribeiro Teixeira
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Evaldo Marchi ; Francisco Vargas Suso ; Leila Antonangelo ; Milena Marques Pagliarelli Acencio ; Vera Luiza Capelozzi

Abstract

Malignant pleural effusion resulting from pleural metastasis of cancers like lung cancer is a common clinical problem with serious repercussions. It is a manifestation of advanced or disseminated neoplasms without the possibility of cure with high morbidity. In general patients present shorter life expectancy and treatments are limited to pleural effusion control that does not benefit all patients and does not inhibit disease progression. Recent studies of pleural neoplasm in murine models have produced pleural effusion and metastasis similar to that found in humans. The use of drugs administered at the first sign of malignant pleural disease, whether in combination with other chemoterapics agents or through another method of administration as into the pleural space, demonstrates the possibility of obtaining a microenvironment less conducive to the development of malignant pleural disease. We intend to study the biomolecular profile of malignant pleural effusion in an animal model and monitor the impact of targeted therapies. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PAGLIARELLI ACENCIO, MILENA MARQUES; PUKA, JULIANA; ALVARENGA, VANESSA ADELIA; MARTINS, VANESSA; PERES DE CARVALHO, MARIANA LOMBARDI; MARCHI, EVALDO; CAPELOZZI, VERA LUIZA; TEIXEIRA, LISETE RIBEIRO. Intrapleural targeted therapies (anti-VEGF and anti-EGFR) in the model of malignant pleural effusion. ONCOTARGET, v. 8, n. 62, p. 105093-105102, DEC 1 2017. (13/11148-9)

PAGLIARELLI ACENCIO, MILENA MARQUES; PUKA, JULIANA; MARCHI, EVALDO; ANTONANGELO, LEILA; TERRA, RICARDO MINGARINI; VARGAS, FRANCISCO SUSO; CAPELOZZI, VERA LUIZA; TEIXEIRA, LISETE RIBEIRO. A modified experimental model of malignant pleural disease induced by lung Lewis carcinoma (LLC) cells. JOURNAL OF TRANSLATIONAL MEDICINE, v. 13, SEP 15 2015. (13/11148-9)