Contribution of tridimensional echocardiography and cardiovascular magnetic resonance imaging (T1 mapping) for low-flow low-gradient aortic stenosis

• Grant number: 13/06149-6
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2014
• End date: April 30, 2017
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Roney Orismar Sampaio
• Grantee: Roney Orismar Sampaio
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Alessandra Gomes de Oliveira ; Vitor Emer Egypto Rosa

Abstract

Aortic Stenosis is one of the most common valvular heart disease in adulthood. It corresponds to over 4.5% of the elderly, resulting in a high number of older people who needs cardiac surgery. One of the highest challenges of clinical practice is how to recognize the cases which will most benefit from aortic valve replacement. The challenge seems to be even higher in those who present small valve area, associated to low pressure gradient and left ventricular dysfunction. Those patients are potentially severe and lots of them do not have a good response after surgery intervention. Further more, many cases are still under diagnosed and are interpreted as moderate aortic stenosis, and it can result in misconduct. The aim of this study is to identify the value of new diagnostic methods like tridimensional echocardiography and cardiovascular resonance imaging with T1 mapping in the diagnosis of low flow low gradient aortic stenosis. Secondary objectives consist in the evaluation of late prognosis of these patients, through evaluating cardiac biomarkers, left ventricular reverse remodeling, left ventricular function and relative percentage of fibrosis in the late post-operative period comparing to the pre-operative period. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ROSA, VITOR E. E.; RIBEIRO, HENRIQUE B.; SAMPAIO, RONEY O.; MORAIS, THAMARA C.; ROSA, MARCELA E. E.; PIRES, LUCAS J. T.; VIEIRA, MARCELO L. C.; MATHIAS, JR., WILSON; ROCHITTE, CARLOS E.; DE SANTIS, ANTONIO S. A. L.; et al. Myocardial Fibrosis in Classical Low-Flow, Low-Gradient Aortic Stenosis Insights From a Cardiovascular Magnetic Resonance Study. CIRCULATION-CARDIOVASCULAR IMAGING, v. 12, n. 5, MAY 2019. (13/06149-6)

TESSARI, FERNANDA CASTIGLIONI; LOPES, MARIA ANTONIETA ALBANEZ A. DE M.; CAMPOS, CARLOS M. M.; ROSA, VITOR EMER EGYPTO; SAMPAIO, RONEY ORISMAR; SOARES, FREDERICO JOSE MENDES MENDONCA; LOPES, RENER ROMULO SOUZA; NAZZETTA, DANIELLA CIAN; DE BRITO JR, FABIO SANDOLI; RIBEIRO, HENRIQUE BARBOSA; et al. Risk prediction in patients with classical low-flow, low-gradient aortic stenosis undergoing surgical intervention. FRONTIERS IN CARDIOVASCULAR MEDICINE, v. 10, p. 9-pg., 2023-06-12. (13/06149-6)