Neural reserve induced by practice of physical activity in adolescence: a study of the brain-derived neurotrophic factor (BDNF), its receptors (TrkB e p75ntr) and intracellular signaling pathways

• Grant number: 14/00035-1
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2014
• End date: December 31, 2016
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Sérgio Gomes da Silva
• Grantee: Sérgio Gomes da Silva
• Host Institution: Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE). Sociedade Beneficente Israelita Brasileira Albert Einstein (SBIBAE). São Paulo , SP, Brazil
• Associated researchers: Francisco Romero Cabral ; Laila Brito Torres Silva Araujo ; Ricardo Mario Arida

Abstract

There are reports that life experiences at early ages such as physical activity in childhood and adolescence can reduce the future risk of brain disorders and enhance lifelong brain functions. However how early physical activity promotes such effects remains unclear. A possible explanation is that physical exercise can increase the expression of neurotrophic factors and stimulate neuronal growth, resulting in a neural reserve which could be extracted throughout the life course. Based on the observation above, the present study was designed to investigate the hypothesis of neural reserve induced by early physical exercise. To do this, we will explore the total number of cell and the expression of brain-derived neurotrophic factor (BDNF), its receptors (tyrosine-related kinase B, TrkB, and neurotrophin receptor, p75ntr) and intracellular signaling pathways. BDNF is member of this family known to play a fundamental role during brain maturation and development, such as branching and remodeling of dendrites and axons, functional maturation of excitatory and inhibitory synapses, and cell death by apoptosis. In this way, the present study will analyze the total number of cell and the cortical and hippocampal BDNF levels, receptors expression and signaling pathways at different life stages (P60, P90, and P120) of rats submitted to a program of physical exercise during adolescence (P21-P60). Our hypothesis is that the neural reverse induced by practice of physical activity may be associated to synthesis of several proteins linked to BDNF/TrkB, as extracellular signal-regulated kinase protein (ERK), protein kinase B (also known as Akt) and cyclic AMP-response element-binding protein (CREB). (AU)

Scientific publications

(10)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DIAZ PLACENCIA, EDUARDO VARELA; SERRA, FERNANDO TADEU; HENRIQUE, JESSICA SALLES; ARIDA, RICARDO MARIO; DA SILVA, SERGIO GOMES. Hippocampal distribution of parvalbumin neurons in female and male rats submitted to the same volume and intensity of aerobic exercise. Neuroscience Letters, v. 690, p. 162-166, JAN 18 2019. (14/00035-1)

DA SILVA, SERGIO GOMES; ARIDA, RICARDO MARIO. Physical activity and brain development. EXPERT REVIEW OF NEUROTHERAPEUTICS, v. 15, n. 9, p. 1041-1051, 2015. (14/00035-1, 09/06953-4)

VICTORINO, ANGELICA BEGATTI; SERRA, FERNANDO TADEU; PINERO, PAMELLA PIMENTEL; DE ALMEIDA, ALEXANDRE APARECIDO; LOPIM, GLAUBER MENEZES; MATIAS JUNIOR, IVAIR; MACHADO, HELIO RUBENS; LENT, ROBERTO; CABRAL, FRANCISCO ROMERO; GOMEZ-PINILLA, FERNANDO; et al. AEROBIC EXERCISE IN ADOLESCENCE RESULTS IN AN INCREASE OF NEURONAL AND NON-NEURONAL CELLS AND IN mTOR OVEREXPRESSION IN THE CEREBRAL CORTEX OF RATS. Neuroscience, v. 361, p. 108-115, OCT 11 2017. (14/00035-1)

SERRA, FERNANDO TADEU; CARVALHO, ANDREA DOMINGUEZ; SILVA ARAUJO, BRUNO HENRIQUE; TORRES, LAILA BRITO; CARDOSO, FABRIZIO DOS SANTOS; HENRIQUE, JESSICA SALLES; DIAZ PLACENCIA, EDUARDO VAREJAO; LENT, ROBERTO; GOMEZ-PINILLA, FERNANDO; ARIDA, RICARDO MARIO; et al. Early exercise induces long-lasting morphological changes in cortical and hippocampal neurons throughout of a sedentary period of rats. SCIENTIFIC REPORTS, v. 9, SEP 23 2019. (14/00035-1)

HENRIQUE, JESSICA SALLES; FRANCA, ERIVELTON FERNANDES; CARDOSO, FABRIZIO DOS SANTOS; SERRA, FERNANDO TADEU; DE ALMEIDA, ALEXANDRE APARECIDO; FERNANDES, JANSEN; ARIDA, RICARDO MARIO; DA SILVA, SERGIO GOMES. Cortical and hippocampal expression of inflammatory and intracellular signaling proteins in aged rats submitted to aerobic and resistance physical training. Experimental Gerontology, v. 110, p. 284-290, SEP 2018. (14/00035-1)

DE ALMEIDA, ALEXANDRE APARECIDO; DA SILVA, SERGIO GOMES; LOPIM, GLAUBER MENEZES; CAMPOS, DIEGO VANNUCCI; FERNANDES, JANSEN; CABRAL, FRANCISCO ROMERO; ARIDA, RICARDO MARIO. Physical exercise alters the activation of downstream proteins related to BDNF-TrkB signaling in male Wistar rats with epilepsy. Journal of Neuroscience Research, v. 96, n. 5, p. 911-920, MAY 2018. (13/12692-4, 14/00035-1, 13/13725-3, 11/50680-2)

DE ALMEIDA, ALEXANDRE APARECIDO; DA SILVA, SERGIO GOMES; LOPIM, GLAUBER MENEZES; CAMPOS, DIEGO VANNUCCI; FERNANDES, JANSEN; CABRAL, FRANCISCO ROMERO; ARIDA, RICARDO MARIO. Resistance Exercise Reduces Seizure Occurrence, Attenuates Memory Deficits and Restores BDNF Signaling in Rats with Chronic Epilepsy. Neurochemical Research, v. 42, n. 4, p. 1230-1239, APR 2017. (13/12692-4, 11/50680-2, 14/00035-1)

CARDOSO, FABRIZIO DOS SANTOS; FRANCA, ERIVELTON FERNANDES; SERRA, FERNANDO TADEU; VICTORINO, ANGELICA BEGATTI; DE ALMEIDA, ALEXANDRE APARECIDO; FERNANDES, JANSEN; CABRAL, FRANCISCO ROMERO; VENANCIO, DANIEL PAULINO; ARIDA, RICARDO MARIO; DA SILVA, SERGIO GOMES. Aerobic exercise reduces hippocampal ERK and p38 activation and improves memory of middle-aged rats. HIPPOCAMPUS, v. 27, n. 8, p. 899-905, AUG 2017. (14/00035-1)

SERRA, FERNANDO TADEU; SILVA ARAUJO, BRUNO HENRIQUE; DIAZ PLACENCIA, EDUARDO VAREJAO; HENRIQUE, JESSICA SALLES; DONA, FLAVIA; TORRES, LAILA BRITO; DA SILVA FERNANDES, MARIA JOSE; ARIDA, RICARDO MARIO; DA SILVA, SWRGIO GOMES. Enriched environment and exercise effects on parvalbumin expression and distribution in the hippocampal formation of developing rats. Brain Research Bulletin, v. 160, p. 85-90, JUL 2020. (09/06953-4, 14/00035-1)

BRAGA, P. L. G.; HENRIQUE, J. S.; ALMEIDA, S. S.; ARIDA, R. M.; DA SILVA, S. GOMES. Factors affecting executive function performance of Brazilian elderly in the Stroop test. Brazilian Journal of Medical and Biological Research, v. 55, n. 1, p. 10-pg., 2022-01-01. (18/16565-0, 14/00035-1)