| Grant number: | 14/00035-1 |
| Support Opportunities: | Regular Research Grants |
| Start date: | July 01, 2014 |
| End date: | December 31, 2016 |
| Field of knowledge: | Biological Sciences - Physiology - Physiology of Organs and Systems |
| Principal Investigator: | Sérgio Gomes da Silva |
| Grantee: | Sérgio Gomes da Silva |
| Host Institution: | Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE). São Paulo , SP, Brazil |
| City of the host institution: | São Paulo |
| Associated researchers: | Francisco Romero Cabral ; Laila Brito Torres Silva Araujo ; Ricardo Mario Arida |
Abstract
There are reports that life experiences at early ages such as physical activity in childhood and adolescence can reduce the future risk of brain disorders and enhance lifelong brain functions. However how early physical activity promotes such effects remains unclear. A possible explanation is that physical exercise can increase the expression of neurotrophic factors and stimulate neuronal growth, resulting in a neural reserve which could be extracted throughout the life course. Based on the observation above, the present study was designed to investigate the hypothesis of neural reserve induced by early physical exercise. To do this, we will explore the total number of cell and the expression of brain-derived neurotrophic factor (BDNF), its receptors (tyrosine-related kinase B, TrkB, and neurotrophin receptor, p75ntr) and intracellular signaling pathways. BDNF is member of this family known to play a fundamental role during brain maturation and development, such as branching and remodeling of dendrites and axons, functional maturation of excitatory and inhibitory synapses, and cell death by apoptosis. In this way, the present study will analyze the total number of cell and the cortical and hippocampal BDNF levels, receptors expression and signaling pathways at different life stages (P60, P90, and P120) of rats submitted to a program of physical exercise during adolescence (P21-P60). Our hypothesis is that the neural reverse induced by practice of physical activity may be associated to synthesis of several proteins linked to BDNF/TrkB, as extracellular signal-regulated kinase protein (ERK), protein kinase B (also known as Akt) and cyclic AMP-response element-binding protein (CREB). (AU)
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