Integrated study of ischemic and dilated cardiopathy: characterization and consolidation of ecocardiography in the evaluation of the coronary anatomy, myocardial function and perfusion

• Grant number: 04/07474-9
• Support Opportunities: Research Projects - Thematic Grants
• Start date: April 01, 2005
• End date: March 31, 2011
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Wilson Mathias Júnior
• Grantee: Wilson Mathias Júnior
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Pesquisadores principais: Edimar Alcides Bocchi ; Eulogio Emilio Martinez Filho ; José Carlos Nicolau
• Associated scholarship(s): 08/05723-2 - Cardiac torsion assessment through speckle-tracking echo in patients with dilated cardiomyopathy, BP.PD

Abstract

Similarly to ischemic heart disease, dilated cardiomyopathy has a high worldwide incidence and prevalence, affecting over 1% of the world population, reaching more than 5% people over 65 years old. Nowadays, the complete evaluation of the clinical data regarding coronary anatomy and functional repercussion of a given atherosclerotic lesion requires several investigative methods, frequently leading to conflicting results, high costs, and sometimes resulting in difficulties in selecting the proper treatment (clinical ou surgical). In the last 30 years, the cardiovascular diagnostic methods as nuclear medicine, magnetic resonance and echocardiography turned to be fundamental tools for the diagnosis of myocardial ischemia and viability. However, false results usually occur in 20% of such studies, therefore opening the doors for new specific research in order to minimize the impact of additional costs originated from new studies or improprieties in the cardiovascular care. The present proposal for this integrated study, that includes several physiopathologic and anatomic data in patients with ischemic heart disease and dilated cardiomyopathy using modern echocardiograpic modalities (Resting 2D and 3Dimentional, and under pharmacologic stresses associated to the use of echocardiographic contrast agent) is based in a wide objective of consolodating its value among all imaging modalities. Therefore, an integrated, large scale study, designed towards the aim of demonstrating the value of each clinical and scientific information obtained through a single exam, at a reasonably low cost, is extremely desirable. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DONADIO ABDUCH, MARIA CRISTINA; SALGO, IVAN; TSANG, WENDY; CAMPOS VIEIRA, MARCELO LUIZ; CRUZ, VICTORIA; LIMA, MARTA; TSUTSUI, JEANE MIKE; MOR-AVI, VICTOR; LANG, ROBERTO M.; MATHIAS, JR., WILSON. Deformação miocárdica pelo speckle tracking na cardiomiopatia dilatada grave. Arquivos Brasileiros de Cardiologia, v. 99, n. 3, p. 834-841, SEP 2012. (08/05723-2, 04/07474-9)