Transcriptomic analysis of brain structures from old and young rats in septic shock

• Grant number: 14/20282-3
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2015
• End date: January 31, 2017
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Marcel Cerqueira Cesar Machado
• Grantee: Marcel Cerqueira Cesar Machado
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Eduardo Moraes Rego Reis ; Fabiano Pinheiro da Silva ; Patricia Severino

Abstract

Sepsis is a disease of the elderly, since the average age of septic individuals is 65 years old. The elderly, in addition, has a higher mortality from this disease.Septic encephalopathy is a common manifestation in sepsis and contributes significantly to a worse prognosis. The present study aims to conduct a large-scale transcriptomic analysis of young and aged rats subjected to septic shock. We intend, therefore, to identify signaling pathways preferentially activated in the elderly, in order to better characterize the particularities of the cerebral involvement in this population, a factor that should contribute significantly to their higher mortality. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BARBEIRO, DENISE FREDIANI; KOIKE, MARCIA KIYOMI; MENDONCA COELHO, ANA MARIA; DA SILVA, FABIANO PINHEIRO; CESAR MACHADO, MARCEL CERQUEIRA. Intestinal barrier dysfunction and increased COX-2 gene expression in the gut of elderly rats with acute pancreatitis. Pancreatology, v. 16, n. 1, p. 52-56, JAN-FEB 2016. (14/20282-3)

CESAR MACHADO, MARCEL CERQUEIRA; DA SILVA, FABIANO PINHEIRO. Intestinal Barrier Dysfunction in Human Pathology and Aging. CURRENT PHARMACEUTICAL DESIGN, v. 22, n. 30, p. 4645-4650, 2016. (14/20282-3)

HAMASAKI, MIKE YOSHIO; BARBEIRO, HERMES VIEIRA; BARBEIRO, DENISE FREDIANI; GOMES CUNHA, DEBORA MARIA; KOIKE, MARCIA KIYOMI; CESAR MACHADO, MARCEL CERQUEIRA; DA SILVA, FABIANO PINHEIRO. "Neuropeptides in the brain defense against distant organ damage". Journal of Neuroimmunology, v. 290, p. 3-pg., 2016-01-15. (14/20282-3)

HAMASAKI, MIKE YOSHIO; BARBEIRO, HERMES VIEIRA; BARBEIRO, DENISE FREDIANI; GOMES CUNHA, DEBORA MARIA; KOIKE, MARCIA KIYOMI; CESAR MACHADO, MARCEL CERQUEIRA; DA SILVA, FABIANO PINHEIRO. ``Neuropeptides in the brain defense against distant organ damage{''}. Journal of Neuroimmunology, v. 290, p. 33-35, JAN 15 2016. (14/20282-3)

HAMASAKI, MIKE YOSHIO; SEVERINO, PATRICIA; PUGA, RENATO DAVID; KOIKE, MARCIA KIYOMI; HERNANDES, CAMILA; BARBEIRO, HERMES VIEIRA; BARBEIRO, DENISE FREDIANI; CESAR MACHADO, MARCEL CERQUEIRA; REIS, EDUARDO MORAES; DA SILVA, FABIANO PINHEIRO. Short-Term Effects of Sepsis and the Impact of Aging on the Transcriptional Profile of Different Brain Regions. Inflammation, v. 42, n. 3, p. 1023-1031, JUN 2019. (14/20282-3)