Cu(II)/Co(III), Cu(II)/Fe(III) and Cu(II)/Ni(II) bimetallic complexes containing Schiff bases: potential catalyzers on the oxidation of catechols

• Grant number: 15/06392-3
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2015
• End date: June 30, 2017
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Edward Ralph Dockal
• Grantee: Edward Ralph Dockal
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

The catalytic activity of enzymes containing Cu(II) e Fe(III) as cofactors on the oxidation of phenols and catechols has inspired the rational design of coordination compounds intended to help understanding the mechanisms that such enzymes act, as to develop new catalyzers to be applied in industrial scale. In this matter, Schiff base transition metal complexes have been used, because such ligands confers to the metal centers a coordination sphere similar to the one presented by the enzymes cofactors in biological environment. Therefore, this project intends to develop a systematic study of bimetallic complexes containing the metal ions Cu(II)/Co(III), Cu(II)/Fe(III) e Cu(II)/Ni(II) with symmetrical and unsymmetrical tetradentate salen type Schiff Bases, aiming to improve the yielding of the catalytic reactions and enhance stereo-selectivity. The ligands and substrates will be characterized by means of: melting point measurements; vibrational spectroscopy; electronic spectroscopy; and 1H and 13C NMR. The new catalysts will be firstly characterized by: melting point measurements; elemental analysis; vibrational spectra; electronic spectra; electrochemical techniques, such as cyclic voltammetry and other techniques that may be needed. The catalytic reactions will be monitored by gas chromatography, GC and the kinetics of some catalytic reactions will also be monitored in the ultraviolet-visible region. The products will be characterized by: vibrational spectra; electronic spectra; 1H e 13C NMR and other techniques that might be needed. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE OLIVEIRA, ALDO S.; VALLI, MARILIA; FERREIRA, LEONARDO L. G.; SOUZA, JULIA M.; KROGH, RENATA; MEIER, LIDIANE; ABREU, HEITOR R.; VOLTOLINI, BRUNA G.; LLANES, LUANA C.; NUNES, RICARDO J.; et al. Novel trypanocidal thiophen-chalcone cruzain inhibitors: structure- and ligand-based studies. Future Medicinal Chemistry, v. 14, n. 11, p. 14-pg., 2022-05-11. (13/07600-3, 15/06392-3, 19/05967-3)

MELLO, LUCAS DOS S.; DA CRUZ JR, JOSE W.; BUCALON, DANIEL H.; ROMERA, SANDRA; DOS SANTOS, MIRIAN P.; LIAO, LUCIANO M.; VIZOTTO, LUCIANA; MARTINS, FELIPE T.; DOCKAL, EDWARD RALPH. Synthesis, characterization and crystal structure of racemic vanadyl and uranyl salen-type complexes. Journal of Molecular Structure, v. 1228, MAR 15 2021. (15/06392-3)

DE OLIVEIRA, ALDO S.; MELLO, LUCAS DOS S.; OGIHARA, CAMILA H.; DORING, THIAGO H.; PALOMINO-SALCEDO, DAVID L.; MICHELAN-DUARTE, SIMONE; FERREIRA, LEONARDO L. G.; SOUZA, JULIA M.; DAVILA-RODRIGUEZ, MARIA JOSE; DA CRUZ JUNIOR, JOSE W.; et al. Diaminomaleonitrile derivatives as new potential antichagasic compounds: a study of structure-activity relationships. Future Medicinal Chemistry, v. 13, n. 24, OCT 2021. (15/06392-3, 13/07600-3)