Reagentes de selenio e telurio em sintese organica.

• Grant number: 00/01011-6
• Support Opportunities: Research Projects - Thematic Grants
• Start date: August 01, 2000
• End date: May 31, 2005
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: João Valdir Comasseto
• Grantee: João Valdir Comasseto
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• City of the host institution: São Paulo

Abstract

Hydrotelluration of alkynes Vinylic substitution reactions with seleno - and tellurolate anions Coupling reactions between vinylic tellurides and lower order cyanocuprates Coupling reaction between alylic cuprates and enoltriflates Coupling reaction between vinylic tellurides and alkynes catalyzed by paltadium. Bergman cyclization of the formed products Chiral aziridine opening by higher order Z vinyl cuprates Coupling of alkyltellurides with organometallic compounds Enzymatic synthesis of chiral y-butyrolactones Reduction of diorganotellurium dichlorides to the corresponding tellurides Hydroxylation of aromatic selenides and tellurides Kinetic resolution of vinylic tellurides Application of the reaction studied in the synthesis of bioactive compounds. (AU)

Scientific publications

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

CUNHA‚ R.L.O.R.; URANO‚ M.E.; CHAGAS‚ J.R.; ALMEIDA‚ P.C.; BINCOLETTO‚ C.; TERSARIOL‚ I.L.S.; COMASSETO‚ J.V.. Tellurium-based cysteine protease inhibitors: evaluation of novel organotellurium (IV) compounds as inhibitors of human cathepsin B. Bioorganic & Medicinal Chemistry Letters, v. 15, n. 3, p. 755-760, 2005. (00/01011-6)