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Lon-term impacts of breastfeeding on maternal metabolism: Participation of microRNAs

Grant number: 15/12680-1
Support Opportunities:Regular Research Grants
Start date: April 01, 2016
End date: March 31, 2018
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Gabriel Forato Anhê
Grantee:Gabriel Forato Anhê
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated researchers:Silvana Auxiliadora Bordin da Silva

Abstract

Several medical studies demonstrate that the duration of breastfeeding period exert a long-term impact on maternal metabolism. Generally, the duration of breastfeeding has an inverse correlation with the relative risk to the development of metabolic syndrome and Type 2 Diabetes. Specifically, mothers who breastfeed for less than 3 months display high LDL and low HDL levels, high levels of fasting TG, increased body weight gain, insulin resistance and increased risk for coronary cardiac disease. In spite of these well-known correlations described by independent groups in different populations, the mechanism by which breastfeeding exerts long-term impacts over maternal metabolism is not yet described. For instance, it is not clear if a high risk lipid profile is due to increased VLDL production and/or increased hepatic TG storage. The present investigation aims to adopt an experimental design based on an animal model subjected to 3 sequential cycles of pregnancy with or without breastfeeding (Lac-0 - no breastfeeding after delivery and Lac-21 - breastfeeding for 21 days after delivery) in order to investigate the long-term metabolic consequences to the mother. Virgin age-matched mice will be used as control. The mice will be subjected to VLDL production assay, insulin and glucose tolerance tests 3 and 6 months after the last cycle of pregnancy. In addition, periodical measurements of fasting TG, HDL, and glycemia will be performed. Fragments of the liver will also be used to determine the TG accumulation, hepatic microRNAs and the expression of key genes related to glucose and lipid metabolism. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VICENTE, JULIA MODESTO; SANTOS-SILVA, JUNIA CAROLINA; TEIXEIRA, CAIO JORDAO; DE SOUZA, DAILSON NOGUEIRA; VETTORAZZI, JEAN FRANCIESCO; FURTUOSO, FABIOLA SALES; ADABO, ISABEL GOUVEIA; SATO, FABIO TAKEO; RAMIREZ VINOLO, MARCO AURELIO; CARNEIRO, EVERARDO MAGALHAES; et al. Long-term increase of insulin secretion in mice subjected to pregnancy and lactation. ENDOCRINE CONNECTIONS, v. 9, n. 4, p. 299-308, . (13/07607-8, 15/12680-1, 17/11138-4)
VICENTE, JULIA MODESTO; SANTOS-SILVA, JUNIA CAROLINA; TEIXEIRA, CAIO JORDAO; DE SOUZA, DAILSON NOGUEIRA; VETTORAZZI, JEAN FRANCIESCO; FURTUOSO, FABIOLA SALES; ADABO, ISABEL GOUVEIA; SATO, FABIO TAKEO; RAMIREZ VINOLO, MARCO AURELIO; CARNEIRO, EVERARDO MAGALHAES; et al. Long-term increase of insulin secretion in mice subjected to pregnancy and lactation. ENDOCRINE CONNECTIONS, v. 9, n. 4, p. 10-pg., . (15/12680-1, 13/07607-8, 17/11138-4)
VICENTE, JULIA MODESTO; TEIXEIRA, CAIO JORDAO; SANTOS-SILVA, JUNIA CAROLINA; DE SOUZA, DAILSON NOGUEIRA; TOBAR, NATALIA; FURTUOSO, FABIOLA SALES; ADABO, ISABEL GOUVEIA; SODRE, FRHANCIELLY SHIRLEY; MURATA, GILSON; BORDIN, SILVANA; et al. The absence of lactation after pregnancy induces long-term lipid accumulation in maternal liver of mice. Life Sciences, v. 217, p. 261-270, . (13/07607-8, 15/12680-1)