Iron overload evaluation by non invasive methods in overweight patients with hyperferritinemia

• Grant number: 15/13524-3
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2016
• End date: June 30, 2018
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Cintia Cercato
• Grantee: Cintia Cercato
• Host Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Claudia Pinto Marques Souza de Oliveira

Abstract

Dysmetabolic iron overload syndrome is characterized by hyperferritinemia, normal serum iron and transferrin saturation associated with mild hepatic overload. This syndrome is reported in 30% of obese patients with non-alcoholic fatty liver disease (NAFLD) and causes a metabolic and histologic worse prognosis. Objective: Analyze non-invasive methods to identify patients with liver iron deposit. Patients and Methods: Forty patients with NAFLD and hyperferritinemia already undergoing liver biopsy will be selected. Patients will be evaluated by metabolic and inflammatory profile, serum hepcidin, distribution of the subunits of ferritin and iron liver pattern in MRI. The data will be compared between patients with and without iron identified on liver biopsy. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BRANISSOA, PAULA PESSIN FABREGA; OLIVEIRA, CLAUDIA PINTO MARQUES SOUZA DE; FILHO, HILTON MUNIZ LEAO; LIMA, FABIANA ROBERTO; SANTOSE, ARITANIA SOUSA; MANCINI, MARCIO CORREA; DE MELO, MARIA EDNA; CARRILHO, FLAIR JOSE; ROCHA, MANOEL DE SOUZA; CLARK, PAUL; et al. Non-invasive methods for iron overload evaluation in dysmetabolic patients. ANNALS OF HEPATOLOGY, v. 27, n. 4, p. 8-pg., 2022-05-24. (15/13524-3)