Effects of the transcranial electric estimulation on the unilateral spatial neglect syndrome after stroke.

• Grant number: 15/14231-0
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2016
• End date: May 31, 2019
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Rodrigo Bazan
• Grantee: Rodrigo Bazan
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated researchers: Adriana Bastos Conforto ; Taiza Elaine Grespan Santos Edwards

Abstract

The aim of this study is to evaluate the effect of Transcranial direct current stimulation (EETCD) on unilateral spatial neglect syndrome (USN) after stroke of the right hemisphere, confirmed by neuroimaging exams. The individuals will be evaluated initially for diagnostic confirmation of USN via tests of double sensorial stimulation, lines and stars cancellation, and line bisection test. After diagnostic confirmation, the patients with USN will be randomized into two groups: 1 - treatment with EETCD (40 patients); 2 - control (sham - 10 patients). Treatment with EETCD would be by anodic and stimulation, on the right and on left, respectively, with 10 patients in each subgroup.The treatment protocol will be applied for 15 sessions, 3 times per week, for 5 weeks, with the patient being evaluated before the beginning of the first session and 1 week after the final session, by a blinded evaluator. Primary outcome: degree of unilateral spatial negligect evaluated by specific tests. Secondary outcome: degree of functional incapacity, autonomy and quality of life, evaluated by specific scales. Statistical analysis will be performed starting with multiple logistic regression for the primary and secondary outcomes adjusted for age, modified Rankin scale and baseline USN score. The statistical analysis will be performed by the software SPSS 15.0 with values of p<0.05 considered statistically significant. (AU)

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LUVIZUTTO, GUSTAVO JOSE; NETO, EDUARDO DE MOURA; DE LIMA RESENDE, LUIZ ANTONIO; DE CARVALHO NUNES, HELIO RUBENS; GOMES GARCIA BETTING, LUIZ EDUARDO; BAZAN, RODRIGO. Crossed Leg Sign Is Associated With Severity of Unilateral Spatial Neglect After Stroke. FRONTIERS IN NEUROLOGY, v. 9, APR 18 2018. (15/14231-0)

GUSTAVO JOSÉ LUVIZUTTO; AUGUSTA FABIANA MOLIGA; GABRIELA RIZZO SOARES RIZZATTI; MARCELO ORTOLANI FOGAROLI; EDUARDO DE MOURA NETO; HÉLIO RUBENS DE CARVALHO NUNES; LUIZ ANTÔNIO DE LIMA RESENDE; RODRIGO BAZAN. Unilateral spatial neglect in the acute phase of ischemic stroke can predict long-term disability and functional capacity. Clinics, v. 73, 2018-05-21. (15/14231-0)

DA SILVA, T. R.; LUVIZUTTO, G. J.; MARTINS, L. G.; DA COSTA, R. D. M.; DE SOUZA, J. T.; WINCKLER, F. C.; SARTOR, L. C. A.; MODOLO, G. P.; FERREIRA, N. C.; RODRIGUES, J. C. S.; et al. Barriers to patient recruitment in a poststroke neurorehabilitation multicenter trial in Brazil. Brazilian Journal of Medical and Biological Research, v. 56, p. 8-pg., 2023-01-01. (15/14231-0)

MIRANDA, LUANA APARECIDA; WINCKLER, FERNANDA CRISTINA; DA SILVA, TAIS REGINA; NUNES, HELIO RUBENS DE CARVALHO; MODOLO, GABRIEL PINHEIRO; FERREIRA, NATALIA CRISTINA; FAVORETTO, DIANDRA B.; AGUIAR, LUAN; BAZAN, SILMEIA GARCIA ZANATI; EDWARDS, TAIZA G. S.; et al. Long-term effect of non-invasive brain stimulation on hemispatial neglect, functional outcomes, and mortality after stroke: ELETRON trial extend. CLINICAL NEUROLOGY AND NEUROSURGERY, v. 249, p. 7-pg., 2025-01-10. (15/14231-0)

KASHIWAGI, FLAVIO TAIRA; EL DIB, REGINA; GOMAA, HUDA; GAWISH, NERMEEN; SUZUMURA, ERICA ARANHA; DA SILVA, TAIS REGINA; WINCKLER, FERNANDA CRISTINA; DE SOUZA, JULI THOMAZ; CONFORTO, ADRIANA BASTOS; LUVIZUTTO, GUSTAVO JOSE; et al. Noninvasive Brain Stimulations for Unilateral Spatial Neglect after Stroke: A Systematic Review and Meta-Analysis of Randomized and Nonrandomized Controlled Trials. NEURAL PLASTICITY, 2018. (15/14231-0)

CARLOS LEONARDO SACOMANI MARQUES; JULI THOMAZ DE SOUZA; MAICON GABRIEL GONÇALVES; TAÍS REGINA DA SILVA; RAFAEL DALLE MOLLE DA COSTA; GABRIEL PINHEIRO MODOLO; JOSÉ EDUARDO CORRENTE; RODRIGO BAZAN; GUSTAVO JOSÉ LUVIZUTTO. VALIDAÇÃO DA ESCALA CATHERINE BERGEGO EM PACIENTES COM NEGLIGÊNCIA ESPACIAL UNILATERAL APÓS ACIDENTE VASCULAR CEREBRAL. Dement. Neuropsychol., v. 13, n. 1, p. 82-88, 2019-03-00. (15/14231-0)

KASHIWAGI, FLAVIO TAIRA; EL DIB, REGINA; GOMAA, HUDA; GAWISH, NERMEEN; SUZUMURA, ERICA ARANHA; DA SILVA, TAIS REGINA; WINCKLER, FERNANDA CRISTINA; DE SOUZA, JULI THOMAZ; CONFORTO, ADRIANA BASTOS; LUVIZUTTO, GUSTAVO JOSE; et al. Noninvasive Brain Stimulations for Unilateral Spatial Neglect after Stroke: A Systematic Review and Meta-Analysis of Randomized and Nonrandomized Controlled Trials. NEURAL PLASTICITY, v. 2018, p. 25-pg., 2018-01-01. (15/14231-0)