| Grant number: | 16/04845-3 |
| Support Opportunities: | Regular Research Grants |
| Start date: | August 01, 2016 |
| End date: | July 31, 2018 |
| Field of knowledge: | Biological Sciences - Immunology - Applied Immunology |
| Principal Investigator: | André Luis Lacerda Bachi |
| Grantee: | André Luis Lacerda Bachi |
| Host Institution: | Pró-Reitoria de Pós-Graduação e Pesquisa. Universidade Cruzeiro do Sul (UNICSUL). São Paulo , SP, Brazil |
Abstract
Currently it is known that the immune system presents significant changes after exercise. However, it was only in the 70s, for various medical reasons, scientific and sports, that the interaction between exercise and the immune system began to be extensively studied. One of the most important aspects in this interaction refers to the observation that athletes performing exhaustive exercise shows increased frequency of incidence of upper respiratory tract infections (URTI) when compared to athletes that performing exercises in moderate intensity or sedentary individuals. Nowadays, it is widely discussed whether the mechanisms causing these manifestations depend solely on the presence of infectious agents or may also be due to allergic and inflammatory events in the upper airways. However, there is consensus in the scientific literature that after a session of exhaustive exercise, the athletes present not only a significant increase systemic of several cytokines, but also relevant reduction in the secretory immunoglobulin A concentration in saliva and upper respiratory mucosa. On the other hand, it is still unclear how the changes in the profile of upper airways cytokines after an high-intensity exercise may favor or prevent the development of these disturbs in the upper respiratory tract. Among some ideas that aimed to reduce both the frequency of incidence and duration of symptoms, can be found the use of probiotics, which are known to present beneficial effects on the individuals´ health. According to literature, probiotics can benefit athletes and their performance indirectly through the maintenance of gastrointestinal function and the prevention of immunosuppressive effects of exhaustive exercise, resulting in decreased susceptibility to disease. However, studies that evaluated the role of probiotics in athletes did not provide consistent evidence of its benefits, especially in elite athletes. Therefore, we propose evaluate the influence of the daily intake of Lactobacillus casei Shirota (LcS) in the systemic and upper airways immune responsiveness of runners, who have previously presented symptoms in the upper airway after a session of high-intensity physical activity, as a marathon race. (AU)
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