Risedronate for osteoporosis treatment in patients with liver cirrhosis and esophageal varices: assessment on safety profile and bone mass

• Grant number: 16/07117-9
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2016
• End date: August 31, 2018
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Fernando Gomes Romeiro
• Grantee: Fernando Gomes Romeiro
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Osteoporosis is the only complication of liver cirrhosis that persists even after liver transplantation. It is a common complication among cirrhotic patients, increasing the risk of fractures and thus affecting morbidity and mortality rates. Early diagnosis and proper treatment are needed to avoid fractures and disability. The treatment requires nutritional supplementation of calcium and vitamin D combined with an anti-reabsortive drug as biphosphonates. In spite of the potential benefits that could be achieved by these drugs, oral biphosphonates can lead to upper digestive mucosal damage, which is a particular concern because cirrhotic patients often have esophageal varices. Therefore, the safety of this approach must be properly appraised in this population. In this study, the risk of upper digestive mucosal damage during oral risedronate treatment will be evaluated in cirrhotic patients who have esophageal varices and osteoporosis. The endoscopic findings will be evaluated through time, and the efficacy of this drug on bone mass will be also assessed. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ROMEIRO, FERNANDO GOMES; IETSUGU, MARJORIE DO VAL; FRANZONI, LETICIA DE CAMPOS; AUGUSTI, LAIS; ALVAREZ, MATHEUS; AMARAL SANTOS, LIVIA ALVES; LIMA, TALLES BAZEI; KOGA, KATIA HIROMOTO; MORIGUCHI, SONIA MARTA; CARAMORI, CARLOS ANTONIO; et al. Which of the branched-chain amino acids increases cerebral blood flow in hepatic encephalopathy? A double-blind randomized trial. NEUROIMAGE-CLINICAL, v. 19, p. 302-310, 2018. (14/22572-9, 16/07117-9, 13/15121-8, 13/11761-2)

DE MOURA, NELCI ANTUNES; ROMEIRO, FERNANDO GOMES. Combining loco-regional treatments in early hepatocellular carcinoma: new achievements overcoming old limitations. TRANSLATIONAL CANCER RESEARCH, v. 6, p. 3-pg., 2017-10-01. (16/07117-9)

AMARAL SANTOS, LIVIA ALVES; ROMEIRO, FERNANDO GOMES. Diagnosis and Management of Cirrhosis-Related Osteoporosis. BIOMED RESEARCH INTERNATIONAL, 2016. (14/22572-9, 16/07117-9)

LIMA, TALLES BAZEIA; AMARAL SANTOS, LIVIA ALVES; DE CARVALHO NUNES, HELIO RUBENS; SILVA, GIOVANNI FARIA; CARAMORI, CARLOS ANTONIO; QI, XINGSHUN; ROMEIRO, FERNANDO GOMES. Safety and efficacy of risedronate for patients with esophageal varices and liver cirrhosis: a non-randomized clinical trial. SCIENTIFIC REPORTS, v. 9, DEC 12 2019. (14/22572-9, 16/07117-9)

SANTOS, LIVIA A. A.; LIMA, TALLES B.; DO VAL IETSUGU, MARJORIE; DE CARVALHO NUNES, HELIO R.; QI, XINGSHUN; ROMEIRO, FERNANDO G.. Anthropometric measures associated with sarcopenia in outpatients with liver cirrhosis. NUTRITION & DIETETICS, v. 76, n. 5, p. 613-619, NOV 2019. (17/25592-9, 16/07117-9, 14/22572-9)

AMARAL SANTOS, LIVIA ALVES; ROMEIRO, FERNANDO GOMES. Diagnosis and Management of Cirrhosis-Related Osteoporosis. BIOMED RESEARCH INTERNATIONAL, v. 2016, p. 12-pg., 2016-01-01. (14/22572-9, 16/07117-9)