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Effects of resistance training on sleep, sleep-wake cycle and skeletal muscle in elderly sarcopenic individuals

Grant number: 16/00521-9
Support type:Regular Research Grants
Duration: October 01, 2016 - March 31, 2019
Field of knowledge:Health Sciences - Collective Health - Public Health
Principal Investigator:Vânia D'Almeida
Grantee:Vânia D'Almeida
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Epidemiological data indicate that in the coming decades there will be an increase in the number of elderly people. In this sense, it is known that about 10% of the elderly will be affected by sarcopenia, a multifactorial syndrome that leads to widespread loss of muscle mass and strength, leading to decreased quality of life, increased fragility, morbidity and mortality. In parallel with aging, it is well described in the literature that older people have phase advance, which leads to changes in the sleep-wake rhythm, and also reduce the time and quality of sleep.Despite the fact that sarcopenia has a multiple etiology little attention is paid to a possible change in the sleep-wake cycle and of sarcopenic elderly altered sleep patterns at higher levels than in non sarcopenic elderly. Interestingly resistance training has frequently been used as way of intervention both for treatment of sarcopenia and to regulate sleep-wake cycle and improve sleep parameters.In this regard, three questions intrigue us, which responses become the objectives of this project: 1) have sarcopenic elderly greater changes in sleep patterns and sleep-wake cycle than non-sarcopenia elderly individuals; 2) sarcopenic seniors who have higher losses in these parameters have also higher impairments of skeletal muscle tissue and; 3) Is the improvement of the health of muscle tissue by the resistance training in the treatment of sarcopenia also related to the improvement of these psychobiological aspects?In order to answer these questions we will conduct a prospective, controlled, single-center study enrolled older health or sarcopenic individuals in two experiments. 1) The experiment aims to answer the first two questions above. To this end, the volunteers will be distributed into 2 groups: Group not sarcopenic elderly (INS) and Group sarcopenic elderly (IS); and the second experiment aims to answer the third question. Thus, the sarcopenic volunteers recruited for the experiment 1 will be distributed in the other 2 groups: Control Group (CG) will receive lectures on change of lifestyle weekly and Group Resistance Training (GTR), which will start the training protocol for 12 weeks immediately after the experiment 1.The GRT group will be submitted to resistance training at 75% of 1 RM (maximum repetition) and GC will attend lectures on lifestyle improvement weekly. All volunteers will be assessed for objective and subjective parameters of sleep evaluation at the sleep-wake cycle, in addition to monitoring the levels of anabolic endocrine substances and catabolic, inflammatory profile, body composition, physical and muscular performance and quality of life before, during and after the trial period. (AU)